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Table 2 Differentially expressed known AD genes in the combined blood and brain datasets in the total sample

From: Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

Gene

Dataset

APOE ɛ2/ɛ3

APOE ɛ3/ɛ3

APOE ɛ3/ɛ4

Total

N

Z-score

P-value

N

Z-score

P-value

N

Z-score

P-value

N

Z-score

P-value

INPP5D

Blood

26

−0.62

0.53

102

1.67

0.10

31

2.12

0.03

179

2.16

0.03

Brain

71

1.80

0.07

355

0.92

0.36

126

0.66

0.51

576

2.30

0.02

Combined

97

1.51

0.13

457

1.29

0.20

157

1.31

0.19

755

2.42

0.02

HLA-DQA1

Blood

26

−1.49

0.14

102

−1.80

0.07

31

0.96

0.34

179

−2.26

0.03

Brain

71

0.30

0.76

355

−3.13

1.7 × 10−3

126

−1.01

0.31

576

−2.23

0.03

Combined

97

−0.16

0.87

457

−2.84

4.6 × 10−3

157

−0.66

0.51

755

−2.42

0.02

SPDYE3

Blood

26

−0.08

0.94

102

−0.76

0.45

31

−0.96

0.34

179

−1.47

0.14

Brain

71

−0.79

0.43

355

−0.97

0.33

126

−2.16

0.03

576

−2.73

6.4 × 10−3

Combined

97

−0.77

0.44

457

−0.96

0.33

157

−2.37

0.02

755

−2.26

0.02

TSPOAP1

Blood

26

−1.38

0.17

102

0.30

0.77

31

−0.16

0.87

179

−0.55

0.58

Brain

71

−1.04

0.30

355

−2.17

0.03

126

−1.85

0.06

576

−3.65

2.6 × 10−4

Combined

97

−1.39

0.16

457

−1.35

0.18

157

−1.82

0.07

755

−2.24

0.03

SIGLEC11

Blood

26

1.43

0.15

102

0.47

0.64

31

0.24

0.81

179

0.33

0.74

Brain

71

1.05

0.29

355

2.46

0.01

126

2.58

9.9 × 10−3

576

3.77

1.6 × 10−4

Combined

97

1.42

0.16

457

1.86

0.06

157

2.54

0.01

755

2.17

0.03

  1. The combined column reflects the meta-analysis results or single batch results in the case of one batch including low gene filtering