Fig. 3

APOE genotype-specific co-expression networks in the blood and brain. a Boxplot for the light green network showing the distribution of eigengene values, which summarize gene expression across a network, among APOE ε4 carriers (+) and non-carriers (-). P-value was calculated using the Student t-test. b Barplot showing significant pathways enriched for established AD genes in the light green network. c Biological subnetwork including established AD genes involved in significant pathways in the light green network. d Heatmap showing the strength of association of seed-gene expression in the brain from the biological subnetwork in c with levels of proteins involved in vascular damage. Asterisks indicate significant associations (P < 4.67 × 10⁻⁴)