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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

Fig. 1

Analysis design and workflow. RNA-sequencing data were obtained from the blood and post-mortem frozen brain of neuropathologically verified AD cases and controls. Data were analyzed in two ways. First, gene co-expression analysis identified networks in the brain that reproduced in the blood. A second analysis identified genes differentially expressed between AD cases in controls in the total sample as well as within APOE genotype groups in both blood and brain. The expression of genes in the co-expression networks that were previously associated with AD by GWAS was tested for associated with AD-related traits measured in the brain. Next, genes in significant co-expression networks and differentially expressed genes in the blood and brain were incorporated as seeds in pathway analysis. Finally, the expression of genes from the most significant pathways was tested for association with levels of several vascular damage proteins. Figure created with BioRender.com

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Alzheimer's Research & Therapy

ISSN: 1758-9193