Table 1 Description of the study population
From: Economic and caregiver impact of Alzheimer’s disease across the disease spectrum: a cohort study
Total | SCC | MCI | Mild AD dementia | Moderate AD dementia | Moderately severe/severe AD dementia | P value* | |
|---|---|---|---|---|---|---|---|
(N = 1998) | (n = 640) | (n = 630) | (n = 212) | (n = 256) | (n = 260) | ||
Age, mean (SD) | 78.62 (8.61) | 74.58 (9.98) | 79.02 (7.62) | 81.69 (6.63) | 82.37 (5.97) | 81.41 (6.63) | < .001 |
Sex, n (%) | |||||||
Female | 1259 (63.00) | 369 (57.66) | 388 (61.59) | 131 (61.79) | 185 (72.27) | 186 (71.54) | < .001 |
Male | 739 (37.00) | 271 (42.34) | 242 (38.41) | 81 (38.21) | 71 (27.73) | 74 (28.46) | |
Education level, n (%) | |||||||
≥ 12 years | 456 (22.4) | 319 (49.84) | 152 (24.13) | 66 (31.13) | 44 (17.19) | 29 (11.15) | < .001 |
< 12 years | 1306 (64.1) | 280 (43.75) | 447 (70.95) | 146 (68.87) | 212 (82.81) | 230 (88.46) | |
Unknown | 276 (13.5) | 41 (6.41) | 31 (4.92) | 0 | 0 | 1 (0.38) | |
MMSE score (out of 30), mean (SD) (n = 1962) | 22.08 (6.14) | 28.02 (1.32) | 23.28 (1.95) | 22.36 (1.90) | 17.12 (1.45) | 10.07 (3.43) | < .001 |
IADL (out of 8), mean (SD) | 5.06 (2.40) | 6.57 (1.79) | 5.49 (2.09) | 4.01 (2.04) | 3.62 (1.97) | 2.54 (1.83) | < .001 |
NPI (out of 144), mean (SD) (n = 1396) | 18.49 (16.11) | 16.41 (15.14) | 15.75 (15.17) | 19.16 (16.69) | 21.01 (15.74) | 23.25 (17.45) | < .001 |
Received treatment for comorbidities, n (%) | |||||||
Hypertension | 1294 (64.76) | 368 (57.50) | 449 (71.27) | 147 (69.34) | 153 (59.77) | 177 (69.08) | < .0001 |
Diabetes mellitus | 360 (18) | 110 (17.19) | 112 (17.78) | 49 (23.11) | 36 (14.06) | 53 (20.38) | .10 |
Hypercholesterolemia | 731 (36.59) | 212 (33.12) | 273 (43.33) | 78 (36.79) | 82 (32.03) | 86 (33.08) | < .0001 |
Depression | 902 (45.15) | 256 (40) | 270 (42.86) | 108 (50.94) | 122 (47.66) | 146 (56.15) | < .0001 |
Anxiety | 650 (32.53) | 188 (29.38) | 210 (33.33) | 63 (29.72) | 85 (33.20) | 104 (40) | .033 |