Table 1 Demographics, clinical information, and biomarkers across diagnostic categories
CN | AD | DLB | FTLD | Down | Others | ||
|---|---|---|---|---|---|---|---|
N | 197 | 518 | 128 | 186 | 225 | 536 | |
AGE, years | Mean (SD) | 53.5 (12.5) | 73.1 (6.88) | 75.7 (5.49) | 70.8 (8.58) | 45.1 (10) | 70 (9.18) |
Median [IQR] | 55 [46–62] | 74 [69–78] | 76 [71–80] | 72 [66–77] | 48 [40–52] | 71 [65–77] | |
SEX, females/males (% females) | 132/65 (67%) | 311/207 (60%) | 64/64 (50%) | 77/109 (41.4%) | 103/122 (45.8%) | 310/226 (57.8%) | |
MMSE score | Mean (SD) | 29.2 (0.889) | 23.6 (4.52) | 24 (4.09) | 24 (5.08) | NAa | 25.4 (4.12) |
Median [IQR] | 29 [29–30] | 25 [22–27] | 24.5 [22–27] | 25 [21–28] | NAa | 27 [24–28] | |
Education, years | Mean (SD) | 15.6 (3.99) | 10.7 (4.72) | 9.18 (5.05) | 12 (5.13) | 15.3 (3.07) | 10.7 (4.93) |
Median [IQR] | 16 [12–20] | 10 [8–13] | 8 [7–12] | 12 [8–16] | NAa | 9 [8–13] | |
APOEε4, APOEε4−/APOEε4+ (%APOEε4+) | 46/151 (23.4%) | 254/251 (50.3%) | 33/93 (26.2%) | 37/139 (21%) | 44/177 (19.9%) | 115/413 (21.8%) | |
Follow-up, years | Mean (SD) | 2.02 (1.99) | 1.09 (1.49) | 3.33 (1.93) | 1.71 (1.47) | 1.76 (2.09) | 0.59 (1.23) |
Median [IQR] | 1.71 [0–2.82] | 0 [0–2.06] | 3.46 [2.07–4.52] | 1.52 [0.242–2.66] | NAa | 0 [0–0.383] | |
Aβ1–42, pg/ml | Mean (SD) | 1148 (397) | 562 (165) | 817 (399) | 938 (446) | 715 (417) | 1000 (500) |
Median [IQR] | 1118 [849–1371] | 556 [432–673] | 703 [542–1009] | 850 [569–1229] | 583 [430–892] | 896 [609–1323] | |
Aβ1–40, pg/ml | Mean (SD) | 11,694 (3595) | 12,790 (3781) | 11,506 (4189) | 10,806 (4357) | 11,673 (4678) | 11,399 (4390) |
Median [IQR] | 11,329 [9238–13,777] | 12,541 [10,125–15,122] | 10,885 [8882–14,234] | 10,140 [7710–13,334] | 11,035 [8346–14,594] | 10,638 [8112–13,986] | |
Aβ1–42/Aβ1–40 | Mean (SD) | 0.0991 (0.0181) | 0.0453 (0.0108) | 0.0727 (0.0263) | 0.0877 (0.0221) | 0.0615 (0.0226) | 0.0862 (0.0225) |
Median [IQR] | 0.104 [0.0986–0.109] | 0.0445 [0.0376–0.0514] | 0.0662 [0.0503–0.0996] | 0.0964 [0.0731–0.103] | 0.0562 [0.0422–0.078] | 0.0943 [0.0665–0.103] | |
tTau, pg/ml | Mean (SD) | 255 (152) | 748 (358) | 456 (334) | 387 (260) | 644 (520) | 334 (231) |
Median [IQR] | 230 [174–291] | 656 [488–915] | 361 [253–525] | 322 [222–456] | 489 [262–870] | 292 [213–378] | |
pTau181, pg/ml | Mean (SD) | 37.3 (27.3) | 122 (60.3) | 70.5 (55.5) | 49.9 (39.2) | 100 (96.8) | 45 (27.4) |
Median [IQR] | 31.6 [24.9–42] | 105 [78.7–145] | 51 [35.7–83] | 39.7 [29.2–54.1] | 63.6 [29.8–151] | 41 [29.3–52.7] | |
NfL, pg/ml | Mean (SD) | 475 (256) | 1330 (1824) | 1108 (570) | 2079 (1836) | 815 (773) | 1488 (1340) |
Median [IQR] | 458 [320–533] | 981 [791–1254] | 918 [719–1297] | 1412 [884–2767] | 614 [357–1014] | 1089 [595–1878] | |
Clinical stage, CN/MCI/dementia (% MCI) | 177/0/0 | 0/296/208 | 2/60/64 | 5/90/80 | NAa | 27/348/125 | |
Amyloid profile (Aβ1–42[−]Ratio[−]/Aβ1–42[−]Ratio[+]/Aβ1–42[+]Ratio[−]/Aβ1–42[+]Ratio[+]) | 165/13/11/8 | 4/154/2/358 | 50/29/7/42 | 120/8/23/35 | 61/37/13/114 | 345/45/47/100 | |