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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Fig. 5

Remote memory consolidation in AD mice is significantly affected by GCSi treatment. A Learning and B contextual memory in AD (Tg2576) mice treated with a GCSi from 12 to 36 weeks of age. Mice were trained at 20 weeks of age. C Contextual memory in AD mice treated with a GCSi from 12 to 52 weeks of age that were re-trained at 36 weeks of age. Statistical comparisons for GCSi-treated AD mice are to sex matched wild type (WT) and to AD controls (****p = 0.0001, ***p = 0.001, **p = 0.01, and *p = 0.05). Error bars represent ± SEM

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Alzheimer's Research & Therapy

ISSN: 1758-9193