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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Fig. 4

GCSi treatment reduces amyloid plaque burden in aged AD mice. A Amyloid plaque number, area, and fraction are significantly reduced in the cortex and hippocampus of AD (Tg2576) mice treated with a GCSi from 70 to 90 weeks of age. B 20X images of amyloid staining in the brains of WT-, AD-, and GCSi-treated AD mice (scale bar = 100 microns). See Figure S4 for 4X images (scale bar = 500 microns). Columns not connected by the same letter are significantly (p = 0.01) different from each other. Error bars represent ± SEM

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