Table 4 MR analysis of the association between educational attainment and AD using the same educational attainment genetic variants
Dataset | Method | OR | 95% CI | P value |
|---|---|---|---|---|
GWAS | IVW | 0.68 | 0.57–0.81 | 8.04E−04 |
Weighted median | 0.65 | 0.51–0.84 | 1.00E–03 | |
MR-Egger | 0.39 | 0.19–0.82 | 1.20E−02 | |
MR-PRESSO | 0.68 | 0.57–0.81 | 2.64E−05 | |
GWAX 2018 | IVW | 1.09 | 1.00–1.19 | 5.00E−02 |
Weighted median | 1.01 | 0.89–1.16 | 8.67E−01 | |
MR-Egger | 0.92 | 0.71–1.17 | 4.88E−01 | |
MR-PRESSO | 1.09 | 1.00–1.19 | 5.17E−02 | |
GWAX 2021 | IVW | 1.88 | 1.62–2.18 | 1.14E−16 |
Weighted median | 1.88 | 1.52–2.32 | 5.14E−09 | |
MR-Egger | 1.88 | 1.04–3.39 | 3.60E−02 | |
MR-PRESSO | 1.88 | 1.62–2.18 | 9.03E−14 | |
GWAS+GWAX 2018 | IVW | 0.99 | 0.91–1.07 | 7.87E−01 |
Weighted median | 0.92 | 0.81–1.04 | 1.63E−01 | |
MR-Egger | 0.95 | 0.74–1.22 | 7.05E−01 | |
MR-PRESSO | 0.99 | 0.91–1.07 | 7.87E−01 | |
GWAS+GWAX 2019 | IVW | 0.96 | 0.93–0.98 | 1.00E−03 |
Weighted median | 0.95 | 0.92–0.99 | 9.00E−03 | |
MR-Egger | 0.91 | 0.81–1.01 | 7.03E−02 | |
MR-PRESSO | 0.96 | 0.93–0.98 | 7.63E−04 | |
GWAS+GWAX 2021 | IVW | 1.21 | 1.08–1.36 | 1.00E-03 |
Weighted median | 1.19 | 1.01–1.40 | 3.90E−02 | |
MR-Egger | 1.03 | 0.65–1.65 | 8.90E−01 | |
MR-PRESSO | 1.21 | 1.08–1.36 | 1.33E−03 |