Table 3 MR analysis of the association between educational attainment and AD

GWAS

IVW

0.71

0.60–0.84

1.02E−04

Weighted median

0.69

0.54–0.88

2.00E−03

MR-Egger

0.39

0.19–0.80

1.00E−02

MR-PRESSO

0.71

0.60–0.84

1.40E−04

GWAX 2018

IVW

1.09

1.00–1.19

5.10E−02

Weighted median

1.01

0.89–1.16

8.62E−01

MR-Egger

0.93

0.72–1.20

5.83E−01

MR-PRESSO

1.09

1.00–1.20

5.26E−02

GWAX 2021

IVW

1.84

1.59–2.13

4.66E−16

Weighted median

1.88

1.54–2.30

1.23E−09

MR-Egger

2.10

1.16–3.79

1.40E−02

MR-PRESSO

1.84

1.59–2.13

1.22E−13

GWAS+GWAX 2018

IVW

1.00

0.91–1.08

9.10E−01

Weighted median

0.92

0.82–1.04

1.70E−01

MR-Egger

0.95

0.74–1.23

7.12E−01

MR-PRESSO

1.00

0.91–1.08

9.10E−01

GWAS+GWAX 2019

IVW

0.96

0.93–0.98

2.00E−03

Weighted median

0.95

0.92–0.99

1.00E−02

MR-Egger

0.90

0.80–1.00

5.20E−02

MR-PRESSO

0.96

0.93–0.98

1.82E−03

GWAS+GWAX 2021

IVW

1.22

1.08–1.36

1.00E−03

Weighted median

1.19

1.02–1.39

3.00E−02

MR-Egger

1.12

0.70–1.79

6.44E−01

MR-PRESSO

1.22

1.08–1.36

1.11E−03