From: Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
 | Genotype distributions | AD Case-Control regression | |||
---|---|---|---|---|---|
Group/model | CN, carrier No. / Total No. (%) | AD, carrier No. / Total No. (%) | CN - AD, MAF (%) | OR (95% CI) | P-value |
rs439401 - T allele tested | |||||
 APOE*4/4 - additive model | |||||
  Discovery – approach 1 | 14 / 237 (5.91 %) | 19 / 1652 (1.15 %) | 3.59 % - 0.64 % | 0.10 (0.04, 0.24) | 1.64E-07 |
  Discovery – approach 2 | 2 / 203 (0.99 %) | 10 / 1577 (0.63 %) | 0.49 % - 0.32 % | 0.47 (0.07, 3.21) | 0.44 |
 APOE*3/4 - WT vs HOM | |||||
  Discovery – approach 1 | 19 / 1401 (1.36 %) | 14 / 2974 (0.47 %) | - | 0.55 (0.38, 0.80) | 1.58E-03 |
  Discovery – approach 2 | 4 / 1339 (0.29 %) | 9 / 2914 (0.31 %) | - | 1.09 (0.61, 1.94) | 0.78 |