Table 4 Summary of outcomes for peripheral brain and blood GSH by qualitative assessment. Studies with 10 or more items rated as “yes” in the qualitative risk of bias assessment were categorized as likely to be “low risk of bias”
Studies and sub-studies (n) | SMD [95% CI] | z | p | X2 | I2 (%) | p | ||
|---|---|---|---|---|---|---|---|---|
Brain GSH | AD (all) | (7) | 0.07 [-1.29, 1.43] | 0.1 | 0.92 | 173.46 | 96.5 | <0.001 |
AD (low risk of bias) | (4) | 0.59 [-2.04, 3.23] | 0.44 | 0.66 | 141.01 | 97.9 | <0.001 | |
MCI (all) | (8) | -0.43 [-1.19, 0.33] | 1.12 | 0.26 | 92.32 | 92.4 | <0.001 | |
MCI (low risk of bias) | (6) | -0.19 [-1.04, 0.67] | 0.43 | 0.67 | 64.08 | 92.2 | <0.001 | |
Blood GSH | AD (all) | (31) | -1.18 [-1.65, -0.71] | 4.9 | <0.001 | 728.87 | 95.9 | <0.001 |
AD (low risk of bias) | (17) | -0.87 [-1.56, -0.20] | 2.53 | 0.01 | 447.49 | 96.4 | <0.001 | |
MCI (all) | (8) | -0.70 [-1.84, 0.44] | 1.21 | 0.23 | 322.88 | 97.8 | <0.001 | |
MCI (low risk of bias) | (6) | -0.65 [-2.13, 0.84] | 0.85 | 0.39 | 315.61 | 98.4 | <0.001 | |