Fig. 3

Forest plot displaying brain GSH concentrations in AD and control subjects, with the subgroup of studies using the MEGA-PRESS protocol at the bottom. Shown are the standardized mean differences (SMD) and 95% confidence intervals (95% CI). Negative values denote lower GSH in AD subjects while positive values denote higher in GSH in AD compared to controls. Pooled SMD [95% CI] = −0.07 [−1.29, 1.43], z=0.1, p=0.92, MEGA-PRESS subgroup: SMD [95% CI] = −1.45 [−1.83, −1.06], z=7.41, p<0.001. ROI indicates the region of interest: PMC posteromedial cortex, PCC posterior cingulate cortex, OCC occipital cortex, HP hippocampus, FC frontal cortex, ACC anterior cingulate cortex