Fig. 8

Peptides do not induce toxic effects in N2a-Tau^RDΔK cells. A MTT-based cytotoxicity assay in the presence of ISAD1 and ISAD1rev peptides. Different peptide concentrations (25, 50, 100, 250 μM) were tested on N2a-Tau^RDΔK cells over 24 h [n = 3; one-way ANOVA with Tukey’s post hoc test; F(10, 151) = 101; ***p ≤ 0.001]. B LDH release of N2a-Tau^RDΔK cells treated with ISAD1 peptides for 24 h [n = 3; one-way ANOVA with Tukey’s post hoc test; F(10, 88) = 1050; *p ≤ 0.05; ***p ≤ 0.001].