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Table 2 Regression coefficients and corresponding weights

From: Cognitive composites for genetic frontotemporal dementia: GENFI-Cog

 

C9orf72

GRN

MAPT

Coef.

Weight

Coef.

Weight

Coef.

Weight

Language

Camel and Cactus Test

  

− 0.004

0.003

− 0.04

0.04

Boston Naming Test

    

− 0.39

0.40

Category fluency

− 0.13

0.09

    

Attention and mental processing speed

Digit span forward

      

Trail Making Test – part A

      

Digit symbol

      

D-KEFS CWIT – colour naming

− 0.06

0.04

  

− 0.09

0.09

D-KEFS CWIT – word naming

− 0.04

0.03

0.09a

   

Executive function

Digit span backward

      

Trail Making Test – part B

− 0.07

0.05

− 0.28

0.23

  

D-KEFS CWIT – ink naming

− 0.29

0.20

− 0.24

0.20

  

Phonemic fluency

  

0.24a

   

Visuoconstruction

Benson figure copy

− 0.09

0.06

    

Memory

Benson figure recall

  

− 0.06

0.05

− 0.01

0.01

FCSRT free recall

− 0.50

0.35

  

− 0.06

0.06

FCSRT total recall

  

− 0.05

0.04

− 0.30

0.31

FCSRT delayed free recall

  

− 0.16

0.13

− 0.01

0.01

FCSRT delayed total recall

      

Social cognition

Facial Emotion Recognition Test

− 0.26

0.18

− 0.42

0.35

− 0.08

0.08

  1. Data are presented as coefficients and weights. Coefficient gives the change in log odds of being a mutation carrier for each Z-score increase in the score on the cognitive test. Weight gives the weighting used when calculating the weighted cognitive composite score
  2. Abbreviations: C9orf72 chromosome 9 open reading frame 72, GRN progranulin, MAPT microtubule-associated protein tau, D-KEFS CWIT Delis-Kaplan Executive Function System Colour-Word Interference Test, FCSRT Free and Cued Selective Reminding Test
  3. aPositive coefficients indicate better performance in mutation carriers compared to controls and were not included in the composite score