| |
n
|
Age (mean ± SD)
|
Sex (f/m)
|
MMSE (median, IQR)
|
CSF (mean ± SD)
|
Plasma (mean ± SD)
|
|---|
|
t-tau (pg/mL)
|
p-tau (pg/mL)
|
Ab42 (pg/mL)
|
LCN2 (ng/mL)
|
|---|
|
Cohort 1
|
|
HC
|
84
|
64.0 ± 5.3
|
26/58
|
NA
|
NA
|
NA
|
NA
|
105.0 ± 53.7
|
|
ND-Dem
|
25
|
60.3 ± 15.2
|
16/9
|
NA
|
484 ± 402
|
NA
|
NA
|
78.9 ± 28.1
|
|
AD
|
74
|
67.6 ± 9.6
|
38/36
|
20.0 (9.0)a
|
622 ± 434
|
100.5 ± 58.3
|
489 ± 317
|
58.3 ± 28.0
|
|
spAD
|
48
|
67.4 ± 9.6
|
22/26
|
22.5 (8.3)
|
510 ± 312
|
85.3 ± 34.1
|
502 ± 266
|
63.3 ± 28.3
|
|
rpAD
|
26
|
67.8 ± 9.6
|
16/10
|
17.0 (10.5)
|
835 ± 540
|
125 ± 73.9
|
384 ± 176
|
49.1 ± 25.7
|
|
MCI-AD
|
14
|
68.7 ± 7.7
|
6/8
|
27.0 (3.0)
|
571 ± 322
|
88.3 ± 27.6
|
569 ± 292
|
103.1 ± 42.2
|
|
MD
|
7
|
70.3 ± 10.5
|
4/3
|
18.0 (12.5)a
|
406 ± 284
|
91.1 ± 27.6
|
491 ± 253
|
53.4 ± 23.9
|
|
VaD
|
28
|
71.4 ± 9.9
|
20/8
|
21 (10.0)a
|
333 ± 325
|
47.3 ± 17.8
|
754 ± 374
|
135.0 ± 120.3
|
|
VCI-MCI
|
16
|
69.5 ± 8.2
|
11/5
|
28.0 (2.3)
|
174 ± 62.0
|
40.7 ± 10.5
|
983 ± 195
|
90.1 ± 24.8
|
|
CJD
|
84
|
65.7 ± 11.8
|
51/33
|
NA
|
8859 ± 7463
|
57.9 ± 19.7
|
482 ± 286
|
102.3 ± 58.8
|
|
FTD
|
30
|
65.6 ± 11.4
|
17/13
|
20.5 (10.3)a
|
371 ± 401
|
59.8 ± 43.6
|
693 ± 293
|
83.2 ± 59.5
|
|
LBD
|
45
|
70.3 ± 9.7
|
17/28
|
21.0 (10.3)a
|
320 ± 210
|
46.9 ± 25.1
|
637 ± 287
|
82.2 ± 31.7
|
|
Cohort 2
|
|
HC
|
28
|
72.1 ± 6.9b
|
19/9
|
NA
|
NA
|
NA
|
NA
|
97.6 ± 49.0
|
|
Amnestic MCI
|
27
|
67.7 ± 9.0
|
12/15
|
NA
|
NA
|
NA
|
NA
|
80.5 ± 21.8
|
|
AD
|
19
|
69.7 ± 6.0
|
8/11
|
NA
|
610 ± 314
|
65.0 ± 28.6
|
390 ± 108
|
65.1 ± 21.0
|
- HC Healthy controls, ND-Dem Non-neurodegenerative neurological diseases with dementia syndrome, AD Alzheimer’s disease (dementia), rpAD Rapidly progressive Alzheimer’s disease, spAD Slowly progressive Alzheimer’s disease, MCI-AD Mild cognitive impairment with positive AD-related biomarkers, MD Mixed dementia (AD plus vascular), VaD Vascular dementia, VCI-MCI Mild vascular cognitive impairment, CJD Creutzfeldt-Jakob disease, FTD Fronto-temporal dementia, LBD Lewy body diseases (dementia with Lewy bodies and Parkinson’s disease dementia), MMSE Mini Mental Status Examination score, SD Standard error, t-Tau CSF Total tau protein, p-tau CSF Phosphorylated tau protein, Abeta42 CSF beta-amyloid 1-42, SD Standard deviation, IQR Interquartile range
- aAvailable MMSE scores (if different from total group size) in AD: n = 71, MD: n = 6, VaD: n = 23, FTD: n = 14; DLB: n = 34
- bFor 3 cases, age was not available
