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Table 4 Multivariate Cox regression analysis of cognitive stage transition

From: Serum neurofilament light chain level as a predictor of cognitive stage transition

 

MCI

CU

Total

Serum NFL

 Lowest tertile

1.00 [ref]

1.00 [ref]

1.00 [ref]

 Middle tertile

5.771 (0.593-56.175)

1.954 (0.196-19.535)

3.541 (0.737–17.019)

 Highest tertile

13.640 (1.346-138.270)*

3.982 (0.443-35.809)

6.346 (1.345–29.937)*

Age

1.030 (0.940-1.804)

0.918 (0.921-1.095)

1.007 (0.953–1.064)

Sex

0.443 (0.109-1.804)

1.888 (0.636-5.598)

1.496 (0.694–3.226)

Baseline MMSE score

0.925 (0.799-1.070)

0.849 (0.700-1.030)

0.866 (0.785–0.955)*

Hippocampal volume, per 1 cm3

0.703 (0.392-1.260)

0.977 (0.499-1.911)

0.899 (0.609–1.327)

Aβ positivity

7.647 (2.041-28.654)*

10.244 (2.996-35.026)**

8.848 (3.614–21.662)**

  1. Data are presented as hazard ratio (95% CI)
  2. MCI mild cognitive impairment, CU cognitive unimpaired, NFL neurofilament light chain, MMSE Mini-Mental State Examination, amyloid-beta
  3. *P < 0.05, **P < 0.01
  4. Adjusted for serum NFL (tertile), age, sex, baseline MMSE score, hippocampal volume, amyloid pathology