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Table 4 Multivariate Cox regression analysis of cognitive stage transition

From: Serum neurofilament light chain level as a predictor of cognitive stage transition

  MCI CU Total
Serum NFL
 Lowest tertile 1.00 [ref] 1.00 [ref] 1.00 [ref]
 Middle tertile 5.771 (0.593-56.175) 1.954 (0.196-19.535) 3.541 (0.737–17.019)
 Highest tertile 13.640 (1.346-138.270)* 3.982 (0.443-35.809) 6.346 (1.345–29.937)*
Age 1.030 (0.940-1.804) 0.918 (0.921-1.095) 1.007 (0.953–1.064)
Sex 0.443 (0.109-1.804) 1.888 (0.636-5.598) 1.496 (0.694–3.226)
Baseline MMSE score 0.925 (0.799-1.070) 0.849 (0.700-1.030) 0.866 (0.785–0.955)*
Hippocampal volume, per 1 cm3 0.703 (0.392-1.260) 0.977 (0.499-1.911) 0.899 (0.609–1.327)
Aβ positivity 7.647 (2.041-28.654)* 10.244 (2.996-35.026)** 8.848 (3.614–21.662)**
  1. Data are presented as hazard ratio (95% CI)
  2. MCI mild cognitive impairment, CU cognitive unimpaired, NFL neurofilament light chain, MMSE Mini-Mental State Examination, amyloid-beta
  3. *P < 0.05, **P < 0.01
  4. Adjusted for serum NFL (tertile), age, sex, baseline MMSE score, hippocampal volume, amyloid pathology