From: Serum neurofilament light chain level as a predictor of cognitive stage transition
MCI | CU | Total | |
---|---|---|---|
Serum NFL | |||
Lowest tertile | 1.00 [ref] | 1.00 [ref] | 1.00 [ref] |
Middle tertile | 5.771 (0.593-56.175) | 1.954 (0.196-19.535) | 3.541 (0.737–17.019) |
Highest tertile | 13.640 (1.346-138.270)* | 3.982 (0.443-35.809) | 6.346 (1.345–29.937)* |
Age | 1.030 (0.940-1.804) | 0.918 (0.921-1.095) | 1.007 (0.953–1.064) |
Sex | 0.443 (0.109-1.804) | 1.888 (0.636-5.598) | 1.496 (0.694–3.226) |
Baseline MMSE score | 0.925 (0.799-1.070) | 0.849 (0.700-1.030) | 0.866 (0.785–0.955)* |
Hippocampal volume, per 1 cm3 | 0.703 (0.392-1.260) | 0.977 (0.499-1.911) | 0.899 (0.609–1.327) |
Aβ positivity | 7.647 (2.041-28.654)* | 10.244 (2.996-35.026)** | 8.848 (3.614–21.662)** |