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Table 3 Univariate Cox regression analysis of cognitive stage transition

From: Serum neurofilament light chain level as a predictor of cognitive stage transition

  MCI
(n = 53)
CU
(n = 146)
Total
(n = 199)
Serum NFL
 Lowest tertile 1.00 [ref] 1.00 [ref] 1.00 [ref]
 Middle tertile 9.265 (1.136-75.587)* 4.968 (0.580-42.529) 6.171 (1.379–27.609)*
 Highest tertile 19.569 (2.133-128.682)** 9.660 (1.224-76.272)* 11.385 (2.664–48.648)**
Age 1.118 (1.043-1.199)** 1.081 (1.013-1.154)* 1.119 (1.070–1.171)**
Sex 0.911 (0.364-2.280) 1.927 (0.698-5.316) 1.599 (0.822–3.111)
Lives alone 1.612 (0.529-4.908) 1.530 (0.432-5.425) 1.522 (0.662-3.498)
BMI 0.863 (0.711-1.047) 1.022 (0.866-1.206) 0.942 (0.831–1.068)
Education 1.016 (0.903-1.143) 0.927 (0.842-1.022) 0.951 (0.888–1.018)
Baseline MMSE score 0.818 (0.730-0.916)** 0.805 (0.702-0.923)** 0.788 (0.729–0.852)**
Initial GDS score 1.019 (0.949-1.094) 1.068 (0.997-1.144) 1.054 (1.004-1.106)*
Hypertension 1.219 (0.494-3.008) 1.007 (0.365-2.778) 1.202 (0.619-2.333)
Diabetes mellitus 1.031 (0.341-3.112) 4.099 (1.457-11.533) 2.073 (0.987-4.354)
Dyslipidemia 0.246 (0.057-1.071) 0.857 (0.305-2.408) 0.429 (0.195-0.944)*
Pill intake of more than three 0.968 (0.392-2.386) 0.662 (0.240-1.828) 0.718 (0.366-1.408)
Hippocampal volume, per 1 cm3 0.628 (0.447-0.882)** 0.666 (0.448-0.989)* 0.600 (0.477–0.756)**
Cortical thickness, per 1 mm 4.090 (0.226-73.875) 0.059 (0.002-1.574) 0.325 (0.032–3.288)
Aβ positivity 5.436 (1.553 – 19.030)** 10.724 (3.584-32.091)** 10.306 (4.594–23.124)**
APOE ε4 carrier 2.546 (0.981-6.661) 1.932 (0.660-5.653) 2.137 (1.057–4.3192)*
Family history of dementia 1.343 (0.526-3.430) 2.085 (0.742-5.858) 1.826 (0.914-3.648)
  1. Data are presented as HR (95% CI)
  2. MCI mild cognitive impairment, CU cognitive unimpaired, NFL neurofilament light chain, BMI body mass index, MMSE Mini-Mental State Examination, GDS geriatric depression scale, HR hazard ratio, amyloid-beta
  3. *P < 0.05, **P < 0.01