Table 3 Univariate Cox regression analysis of cognitive stage transition

 Lowest tertile

1.00 [ref]

1.00 [ref]

1.00 [ref]

 Middle tertile

9.265 (1.136-75.587)*

4.968 (0.580-42.529)

6.171 (1.379–27.609)*

 Highest tertile

19.569 (2.133-128.682)**

9.660 (1.224-76.272)*

11.385 (2.664–48.648)**

Age

1.118 (1.043-1.199)**

1.081 (1.013-1.154)*

1.119 (1.070–1.171)**

Sex

0.911 (0.364-2.280)

1.927 (0.698-5.316)

1.599 (0.822–3.111)

Lives alone

1.612 (0.529-4.908)

1.530 (0.432-5.425)

1.522 (0.662-3.498)

BMI

0.863 (0.711-1.047)

1.022 (0.866-1.206)

0.942 (0.831–1.068)

Education

1.016 (0.903-1.143)

0.927 (0.842-1.022)

0.951 (0.888–1.018)

Baseline MMSE score

0.818 (0.730-0.916)**

0.805 (0.702-0.923)**

0.788 (0.729–0.852)**

Initial GDS score

1.019 (0.949-1.094)

1.068 (0.997-1.144)

1.054 (1.004-1.106)*

Hypertension

1.219 (0.494-3.008)

1.007 (0.365-2.778)

1.202 (0.619-2.333)

Diabetes mellitus

1.031 (0.341-3.112)

4.099 (1.457-11.533)

2.073 (0.987-4.354)

Dyslipidemia

0.246 (0.057-1.071)

0.857 (0.305-2.408)

0.429 (0.195-0.944)*

Pill intake of more than three

0.968 (0.392-2.386)

0.662 (0.240-1.828)

0.718 (0.366-1.408)

Hippocampal volume, per 1 cm³

0.628 (0.447-0.882)**

0.666 (0.448-0.989)*

0.600 (0.477–0.756)**

Cortical thickness, per 1 mm

4.090 (0.226-73.875)

0.059 (0.002-1.574)

0.325 (0.032–3.288)

Aβ positivity

5.436 (1.553 – 19.030)**

10.724 (3.584-32.091)**

10.306 (4.594–23.124)**

APOE ε4 carrier

2.546 (0.981-6.661)

1.932 (0.660-5.653)

2.137 (1.057–4.3192)*

Family history of dementia

1.343 (0.526-3.430)

2.085 (0.742-5.858)

1.826 (0.914-3.648)