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Table 1 Baseline characteristics of the MCI participants according to the initial serum NFL levels

From: Serum neurofilament light chain level as a predictor of cognitive stage transition

  Lowest tertile
(n = 18)
Middle tertile
(n = 18)
Highest tertile
(n = 17)
P-value*
Mean serum NFL, pg/ml 12.9 ± 4.0c 21.2 ± 3.4b 39.7 ± 15.5a <0.001**
Range of serum NFL 5.6-18.3 18.4-23.8 24.0-84.5  
Demographics
 Age, years 67.8 ± 7.0b 72.8 ± 7.6b 79.4 ± 6.3a <0.001**
 Sex, female 9 (50.0) 8 (44.4) 6 (35.3) 0.676*
 Lives alone 4 (22.2) 1 (5.6) 3 (17.6) 0.354*
 BMI, kg/m2 24.0 ± 2.4 24.2 ± 2.8 24.4 ± 2.4 0.920**
 Education, years 9.4 ± 3.6 9.3 ± 4.4 9.2 ± 4.3 0.993**
MMSE score, median (IQR) 25.0 (22.0 – 27.25) 24.0 (20.0 - 26.0) 21.0 (19.5-23.5) 0.041†
CDR score, median (IQR) 1.0 (1.0-1.0) 1.0 (1.0-1.0) 1.0 (1.0-1.0) 0.591†
CDR-SOB score, median (IQR) 1.0 (1.0-1.25) 1.0 (1.0-2.0) 2.0 (1.0-2.0) 0.129†
Gdps score, median (IQR) 8.5 (4.75-13.25) 10.0 (3.0-18.75) 9.0 (4.0-13.0) 0.727†
Medical history
 Hypertension 7 (38.9) 9 (50.0) 9 (52.9) 0.677*
 Diabetes mellitus 4 (22.2) 2 (11.1) 5 (29.4) 0.618‡
 Dyslipidemia 7 (38.9) 7 (38.9) 1 (5.9) 0.045*
 Coronary artery disease 2 (11.1) 1 (5.6) 0 (0.0) 0.159‡
 Cerebrovascular disease 0 (0.0) 1 (5.6) 1 (5.9) 0.362‡
 Smoking 1 (5.6) 0 (0.0) 1 (5.9) 0.974‡
 Pill intake of more than three 10 (55.6) 10 (55.6) 9 (52.9) 0.984*
Hippocampal volume, cm3 5.1 ± 0.7a 4.3 ± 1.4b 4.4 ± 0.5ab 0.033**
Cortical thickness, mm 3.01 ± 0.15 3.10 ± 0.17 3.07 ± 0.11 0.212**
Aβ positivity 7/17 (41.2) 11/17 (64.7) 8/15 (53.3) 0.389*
APOE ε4 carrier 3 (16.7) 6 (33.3) 3 (17.6) 0.928‡
Family history of dementia 5 (274.8) 6 (33.3) 5 (29.4) 0.933*
Cognitive stage transition 1 (5.6)b 7 (38.9)ab 11 (64.7)a 0.001*
  1. Data are presented as mean ± standard deviation or number (%), unless otherwise indicated
  2. NFL neurofilament light chain, MMSE Mini-Mental State Examination, IQR interquartile range, CDR-SOB Clinical Dementia Rating Scale Sum of Boxes, Gdps Geriatric Depression Scale, amyloid-beta
  3. Based on *Pearson’s chi-square test, **analysis of variance, the †Kruskal–Wallis test, or ‡linear by linear association
  4. a>b>c. Pearson’s chi-square test with Bonferroni correction or Tukey’s post hoc comparisons was performed to assess for significant differences among the subgroups