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Table 3 Correlation analysis between metabolomics, biochemical and neuropsychological variables within the four study groups stratified according to the ApoE-ε4 genotype and sex (Pearson’s correlation coefficients are shown in brackets). Abbreviations are defined in Table S1

From: Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

  Fε4- Mε4- Fε4+ Mε4+
Biochemical variables
Glucose FFAs: C14:0 (0.29), C16:0 (0.33), C16:1 (0.27), C17:0 (0.24), C18:0 (0.19), C18:1 (0.35), C18:2 (0.27), C18:3 (0.37), C20:4 (0.31), C22:4 (0.47), C22:5 (0.28), C22:6 (0.21)
ACs: C2 (0.28), C3 (0.19), C8 (0.19), C10 (0.19), C12 (0.24), C14 (0.27), C16 (0.22), C18:1 (0.18)
Others: creatinine (-0.19), lactic acid (0.26), pantothenic acid (0.21)
  FFAs: C14:0 (0.32), C16:0 (0.41), C17:0 (0.32), C18:0 (0.39), C18:1 (0.30), C18:2 (0.26), C18:3 (0.26), C20:4 (0.35), C22:4 (0.45), C22:5 (0.36), C22:6 (0.26)
ACs: C2 (0.23)
Others: creatinine (-0.37), lactic acid (0.26), pyruvic acid (0.28)
FFAs: C16:1 (0.43), C18:1 (0.50), C18:3 (0.46)
Creatinine ACs: C2 (0.25), C3 (0.18), C4 (0.28), C11 (0.14), C14 (0.17), C18:2 (0.19)
Others: creatine (-0.24), pantothenic acid (0.31)
FFAs: C16:0 (-0.17), C18:0 (-0.19), C18:1 (-0.18), C20:4 (-0.18), C22:4 (-0.25)
ACs: C2 (0.25), C3 (0.21), C4 (0.35), C11 (0.18), C14 (0.17)
ACs: C8 (0.33), C10 (0.39), C11 (0.41), C12 (0.36)
Others: pantothenic acid (0.24)
FFAs: C18:0 (-0.39)
ACs: C3 (0.37), C4 (0.56)
Cholesterol FFAs: C22:4 (-0.11)
ACs: C1 (-0.16), C2 (-0.15)
Others: pantothenic acid (-0.20)
FFAs: C20:4 (0.22), C20:5 (0.19) FFAs: C20:4 (0.42), C22:4 (0.26)
Others: niacinamide (0.33)
FFAs: C17:0 (0.42), C18:2 (0.44)
LDL-C FFAs: C16:1 (-0.14), C22:4 (-0.16)
Others: pantothenic acid (-0.21)
FFAs: C20:4 (0.21)
Others: niacinamide (0.20), creatine (0.20)
FFAs: C20:4 (0.30),
Others: niacinamide (0.31)
FFAs: C17:0 (0.46),
HDL-C FFAs: C18:1 (0.12), C20:4 (0.15), C22:6 (0.13)
ACs: C8 (0.20), C10 (0.21), C11 (0.22), C12 (0.22)
FFAs: C14:0 (0.19)
ACs: C3 (-0.18), C18:1 (-0.22)
Others: pantothenic acid (-0.21), niacinamide (-0.24)
FFAs: C20:5 (0.34), C22:6 (0.21)
Others: creatine (0.33)
Others: creatinine (-0.42), pyruvic acid (-0.44)
Triglycerides FFAs: C14:0 (0.16), C16:0 (0.15), C22:4 (0.22)
ACs: C3 (0.18), C14 (0.21), C16 (0.24)
Others: thiamine (-0.18)
ACs: C16 (-0.11)
Others: niacinamide (0.34), pyruvic acid (0.25), citric acid (-0.23)
FFAs: C14:0 (0.38), C16:0 (0.40), C17:0 (0.30), C18:0 (0.34), C18:1 (0.33), C18:2 (0.25), C18:3 (0.28), C20:4 (0.36), C22:4 (0.42), C22:5 (0.30)
Others: pyruvic acid (0.32)
FFAs: C14:0 (0.50), C17:0 (0.41), C18:2 (0.37), C18:3 (0.44), C22:5 (0.38)
Neuropsychological variables
MMSE   FFAs: C22:5 (0.19)
ACs: C8 (0.22), C10 (0.19), C12 (0.23)
Others: pantothenic acid (-0.20)
  FFAs: C22:4 (-0.43)
ACs: C2 (-0.38), C14 (-0.43), C16 (-0.39)
Others: creatine (0.54), pyruvic acid (-0.44)
BVRT   Others: pantothenic acid (-0.22) Others: creatine (0.31) Others: citric acid (0.72)
IST FFAs: C16:0 (-0.14), C16:1 (-0.16), C18:1 (-0.14), C22:4 (-0.14) FFAs: C18:3 (0.17), C20:4 (0.24), C22:4 (0.20), C22:5 (0.19), C22:6 (0.19) FFAs: C22:4 (-0.22) FFAs: C16:0 (0.44), C18:0 (0.54), C18:1 (0.40), C18:2 (0.37), C18:3 (0.40), C20:5 (0.62), C22:6 (0.66)
Others: citric acid (0.43)
TMTA ACs: C14 (-0.15), C18:1 (-0.15) FFAs: C16:1 (0.19), C18:3 (0.23), C20:4 (0.24), C20:5 (0.28), C22:4 (0.19), C22:5 (0.28), C22:6 (0.33) ACs: C3 (0.31), C4 (0.34), C16 (0.25), C18:1 (0.27) FFAs: C20:4 (0.71), C22:6 (0.43)
Others: niacinamide (0.46)
TMTB FFAs: C22:4 (-0.13), C22:5 (-0.11)
Others: citric acid (0.15)
Others: niacinamide (-0.22) FFAs: C16:0 (0.30), C18:0 (0.34), C20:4 (0.24)
Others: citric acid (0.29), lactic acid (0.43)
Others: creatinine (-0.58)
  1. Abbreviations: F, female individuals non-carrying the ε4 allele of the apolipoprotein E gene; Mε4-, male individuals non-carrying the ε4 allele of the apolipoprotein E gene; Fε4+, female individuals carrying the ε4 allele of the apolipoprotein E gene; Mε4+, male individuals carrying the ε4 allele of the apolipoprotein E gene; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; MMSE, Mini-Mental State Examination test; BVRT, Benton Visual Retention Test; IST, Isaac’s Set Test; TMTA, Trail-Making Test part A; TMTB, Trail-Making Test part B; FFAs, free fatty acids; ACs, acyl-carnitines.