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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex

Fig. 2

Numbers and ratios of VENs and GABRQ-immunoreactive pyramidal neurons in bvAD compared to tAD, bvFTD and controls. A The number of VENs counted based on GABRQ-immunohistochemistry across groups, representing the total number of GABRQ-immunopositive VENs and GABRQ-immunonegative VENs, showing no significant differences between bvAD, typical AD, and controls. B The number of GABRQ-immunoreactive pyramidal neurons) across groups, showing no significant differences between bvAD, typical AD, and controls and significantly higher numbers in bvAD and typical AD compared to bvFTD. C The ratio of total VENs (GABRQ-immunopositive and –negative) over all layer 5 neurons in order to correct for effects of neurodegenerative processes, showing no differences between bvAD, typical AD, and controls in turn and significantly lower VENs in bvFTD than controls. D The ratio of GABRQ-immunoreactive pyramidal neurons over all layer 5 neurons, showing no differences between bvAD, typical AD and controls and significantly higher ratios in bvAD and typical AD compared to bvFTD. Results were assessed using emmeans post-hoc tests, adjusting for age, using a Bonferroni correction in R version 4.0.2

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Alzheimer's Research & Therapy

ISSN: 1758-9193