|
Outcome measure
|
Beta
|
Lower CI
|
Upper CI
|
p value
|
Beta
|
Lower CI
|
Upper CI
|
p value
|
|---|
| |
zNfL Q4
|
zNfL Q4 * Time
|
|
ADAS-Cog13
|
0.400
|
0.106
|
0.694
|
0.008
|
0.208
|
0.094
|
0.321
|
< 0.001
|
|
Logical Memory - Immediate
|
−0.334
|
−0.619
|
−0.048
|
0.022
|
−0.083
|
−0.166
|
0.000
|
0.050
|
|
Logical Memory - Delayed
|
−0.370
|
−0.662
|
−0.078
|
0.013
|
−0.062
|
−0.132
|
0.008
|
0.082
|
|
Trail Making Test B
|
0.189
|
−0.089
|
0.466
|
0.184
|
0.057
|
−0.020
|
0.135
|
0.148
|
|
Hippocampal volume
|
−0.523
|
−0.781
|
−0.265
|
< 0.001
|
−0.051
|
−0.082
|
−0.021
|
0.001
|
| |
zT-tau Q4
|
zT-tau Q4 * Time
|
|
ADAS-Cog13
|
0.254
|
−0.033
|
0.542
|
0.084
|
0.087
|
−0.027
|
0.201
|
0.136
|
|
Logical Memory - Immediate
|
−0.208
|
−0.487
|
0.071
|
0.144
|
−0.086
|
−0.168
|
−0.004
|
0.042
|
|
Logical Memory - Delayed
|
−0.322
|
−0.607
|
−0.037
|
0.027
|
0.019
|
−0.051
|
0.088
|
0.598
|
|
Trail Making Test B
|
0.083
|
−0.188
|
0.354
|
0.549
|
0.003
|
−0.074
|
0.080
|
0.938
|
|
Hippocampal volume
|
−0.061
|
−0.313
|
0.191
|
0.636
|
−0.001
|
−0.031
|
0.030
|
0.976
|
| |
Q4 Both
|
Q4 Both * Time
|
|
ADAS-Cog13
|
0.526
|
0.177
|
0.874
|
0.003
|
0.135
|
−0.002
|
0.271
|
0.054
|
|
Logical Memory - Immediate
|
−0.477
|
−0.816
|
−0.138
|
0.006
|
−0.069
|
−0.170
|
0.032
|
0.183
|
|
Logical Memory - Delayed
|
−0.391
|
−0.738
|
−0.045
|
0.027
|
−0.079
|
−0.164
|
0.006
|
0.069
|
|
Trail Making Test B
|
0.404
|
0.075
|
0.734
|
0.017
|
0.015
|
−0.081
|
0.111
|
0.759
|
|
Hippocampal volume
|
−0.028
|
−0.334
|
0.278
|
0.856
|
−0.010
|
−0.046
|
0.027
|
0.603
|
- For the ADAS-Cog13 and Trail Making Test B, a higher score indicates worse performance. Cognitive measures were z-scored prior to analysis except Trail Making Test B, which was z log-transformed. Hippocampal volume measures were adjusted for total intracranial volume. Reference level is having both biomarkers in the bottom three quartiles. Models were all adjusted for age, sex, and education
- ADAS-Cog13 Alzheimer’s disease assessment scale-cognitive subscale 13 tasks, NfL neurofilament light, Q4 top quartile, T-tau total tau
