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Table 5 Cross-sectional and longitudinal associations for Q4 baseline plasma NfL, T-tau, or both in ADNI

From: Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes

Outcome measure

Beta

Lower CI

Upper CI

p value

Beta

Lower CI

Upper CI

p value

 

zNfL Q4

zNfL Q4 * Time

 ADAS-Cog13

0.400

0.106

0.694

0.008

0.208

0.094

0.321

< 0.001

 Logical Memory - Immediate

−0.334

−0.619

−0.048

0.022

−0.083

−0.166

0.000

0.050

 Logical Memory - Delayed

−0.370

−0.662

−0.078

0.013

−0.062

−0.132

0.008

0.082

 Trail Making Test B

0.189

−0.089

0.466

0.184

0.057

−0.020

0.135

0.148

 Hippocampal volume

−0.523

−0.781

−0.265

< 0.001

−0.051

−0.082

−0.021

0.001

 

zT-tau Q4

zT-tau Q4 * Time

 ADAS-Cog13

0.254

−0.033

0.542

0.084

0.087

−0.027

0.201

0.136

 Logical Memory - Immediate

−0.208

−0.487

0.071

0.144

−0.086

−0.168

−0.004

0.042

 Logical Memory - Delayed

−0.322

−0.607

−0.037

0.027

0.019

−0.051

0.088

0.598

 Trail Making Test B

0.083

−0.188

0.354

0.549

0.003

−0.074

0.080

0.938

 Hippocampal volume

−0.061

−0.313

0.191

0.636

−0.001

−0.031

0.030

0.976

 

Q4 Both

Q4 Both * Time

 ADAS-Cog13

0.526

0.177

0.874

0.003

0.135

−0.002

0.271

0.054

 Logical Memory - Immediate

−0.477

−0.816

−0.138

0.006

−0.069

−0.170

0.032

0.183

 Logical Memory - Delayed

−0.391

−0.738

−0.045

0.027

−0.079

−0.164

0.006

0.069

 Trail Making Test B

0.404

0.075

0.734

0.017

0.015

−0.081

0.111

0.759

 Hippocampal volume

−0.028

−0.334

0.278

0.856

−0.010

−0.046

0.027

0.603

  1. For the ADAS-Cog13 and Trail Making Test B, a higher score indicates worse performance. Cognitive measures were z-scored prior to analysis except Trail Making Test B, which was z log-transformed. Hippocampal volume measures were adjusted for total intracranial volume. Reference level is having both biomarkers in the bottom three quartiles. Models were all adjusted for age, sex, and education
  2. ADAS-Cog13 Alzheimer’s disease assessment scale-cognitive subscale 13 tasks, NfL neurofilament light, Q4 top quartile, T-tau total tau