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Table 5 Cross-sectional and longitudinal associations for Q4 baseline plasma NfL, T-tau, or both in ADNI

From: Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes

Outcome measure Beta Lower CI Upper CI p value Beta Lower CI Upper CI p value
  zNfL Q4 zNfL Q4 * Time
 ADAS-Cog13 0.400 0.106 0.694 0.008 0.208 0.094 0.321 < 0.001
 Logical Memory - Immediate −0.334 −0.619 −0.048 0.022 −0.083 −0.166 0.000 0.050
 Logical Memory - Delayed −0.370 −0.662 −0.078 0.013 −0.062 −0.132 0.008 0.082
 Trail Making Test B 0.189 −0.089 0.466 0.184 0.057 −0.020 0.135 0.148
 Hippocampal volume −0.523 −0.781 −0.265 < 0.001 −0.051 −0.082 −0.021 0.001
  zT-tau Q4 zT-tau Q4 * Time
 ADAS-Cog13 0.254 −0.033 0.542 0.084 0.087 −0.027 0.201 0.136
 Logical Memory - Immediate −0.208 −0.487 0.071 0.144 −0.086 −0.168 −0.004 0.042
 Logical Memory - Delayed −0.322 −0.607 −0.037 0.027 0.019 −0.051 0.088 0.598
 Trail Making Test B 0.083 −0.188 0.354 0.549 0.003 −0.074 0.080 0.938
 Hippocampal volume −0.061 −0.313 0.191 0.636 −0.001 −0.031 0.030 0.976
  Q4 Both Q4 Both * Time
 ADAS-Cog13 0.526 0.177 0.874 0.003 0.135 −0.002 0.271 0.054
 Logical Memory - Immediate −0.477 −0.816 −0.138 0.006 −0.069 −0.170 0.032 0.183
 Logical Memory - Delayed −0.391 −0.738 −0.045 0.027 −0.079 −0.164 0.006 0.069
 Trail Making Test B 0.404 0.075 0.734 0.017 0.015 −0.081 0.111 0.759
 Hippocampal volume −0.028 −0.334 0.278 0.856 −0.010 −0.046 0.027 0.603
  1. For the ADAS-Cog13 and Trail Making Test B, a higher score indicates worse performance. Cognitive measures were z-scored prior to analysis except Trail Making Test B, which was z log-transformed. Hippocampal volume measures were adjusted for total intracranial volume. Reference level is having both biomarkers in the bottom three quartiles. Models were all adjusted for age, sex, and education
  2. ADAS-Cog13 Alzheimer’s disease assessment scale-cognitive subscale 13 tasks, NfL neurofilament light, Q4 top quartile, T-tau total tau