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Table 4 ADNI participant baseline characteristics

From: Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes

Characteristic Data available CU Data available MCI p value
Median (IQR) / N (%) Median (IQR) / N (%)
Age (years) 190 75.6 (72.5, 78.4) 197 74.9 (70.2, 79.9) 0.296a
Male 190 105 (55.3%) 197 132 (67.0%) 0.018b
Education (years) 190 16.0 (14.0, 18.0) 197 16 (14, 18) 0.538a
≥ 1 APOE ε4 190 50 (26.3%) 197 103 (52.3%) <0.001b
Plasma NfL (pg/mL) 190 29.15 (22.90, 39.15) 197 36.9 (27.600, 48.400) <0.001a
Plasma total tau (pg/mL) 190 2.53 (1.78, 3.14) 197 2.62 (1.770, 3.450) 0.324a
Time since baseline (years) 190 3.0 (3.0, 4.0) 197 3.0 (2.0, 3.1) <0.001a
Cognitive test
 MMSE 190 29 (29, 30) 197 27 (25, 28) <0.001a
 ADAS-Cog13 190 9.50 (6.00, 12.33) 197 19 (14.670, 23.670) <0.001a
 Logical Memory - Immediate Recall 190 13 (12, 16) 197 7 (5, 9) <0.001a
 Logical Memory - Delayed Recall 190 12 (10, 15) 197 3 (1, 6) <0.001a
 Trail Making Test Part B (sec, max 300) 190 80 (62, 100.75) 197 108 (78, 173) <0.001a
Hippocampal volume (adjusted for TIV) 190 −0.497 (−0.892, −0.097) 197 −1.379 (−1.975, −0.819) <0.001a
  1. aKruskal-Wallis rank sum test
  2. bPearson’s chi-square test
  3. ADAS-Cog13 Alzheimer’s disease assessment scale-cognitive subscale 13 tasks (higher score = worse performance), APOE apolipoprotein E, IQR interquartile range, MCI mild cognitive impairment, NfL neurofilament light