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Table 2 Cross-sectional and longitudinal cognition in those with baseline plasma NfL, T-tau, or both in the top quartile

From: Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes

Cognitive measure (z-score) Beta Lower CI Upper CI p value Beta Lower CI Upper CI p value
  zNfL Q4 zNfL Q4 * Time
 Memory 0.002 −0.169 0.174 0.979 −0.083 −0.106 −0.060 < 0.001
 Language −0.132 −0.305 0.041 0.134 −0.086 −0.114 −0.059 < 0.001
 Attention −0.208 −0.369 −0.047 0.012 −0.093 −0.118 −0.068 < 0.001
 Visuospatial −0.067 −0.235 0.102 0.439 −0.065 −0.087 −0.043 < 0.001
 Global −0.134 −0.295 0.028 0.105 −0.102 −0.126 −0.078 < 0.001
  zT-tau Q4 zT-tau Q4 * Time
 Memory −0.015 −0.174 0.143 0.851 −0.008 −0.030 0.014 0.453
 Language −0.086 −0.246 0.074 0.292 −0.014 −0.040 0.012 0.283
 Attention −0.061 −0.209 0.089 0.427 −0.010 −0.033 0.014 0.408
 Visuospatial −0.021 −0.177 0.134 0.787 −0.002 −0.022 0.019 0.865
 Global −0.053 −0.202 0.095 0.481 −0.014 −0.036 0.009 0.240
  Q4 Both Q4 Both * Time
 Memory −0.261 −0.462 −0.059 0.011 −0.071 −0.099 −0.043 < 0.001
 Language −0.146 −0.350 0.058 0.162 −0.077 −0.110 −0.044 < 0.001
 Attention −0.221 −0.410 −0.031 0.023 −0.094 −0.124 −0.063 < 0.001
 Visuospatial −0.104 −0.302 0.094 0.305 −0.042 −0.069 −0.016 0.002
 Global −0.260 −0.449 −0.070 0.008 −0.090 −0.119 −0.061 < 0.001
  1. The reference group is having both biomarkers in the bottom three quartiles. Models adjust for age, sex, education, and whether or not the cognitive test had been previously administered
  2. CI confidence interval, NfL neurofilament light, Q4 top quartile, T-tau total tau