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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes

Fig. 2

Amyloid-dependent associations between biomarkers with cross-sectional and longitudinal cognitive and neuroimaging outcomes in the MCSA. Relationships between plasma NfL or T-tau and cognition and neuroimaging in the MCSA stratified by amyloid-beta (Ab) status (elevated Ab PET, A+; non-elevated PET, A−). A Associations of baseline plasma NfL or T-tau with cognitive z-scores at cross-section. B Associations of baseline plasma NfL or T-tau with longitudinal cognitive outcomes. C Associations of baseline plasma NfL or T-tau with cross-sectional neuroimaging measures. D Associations of baseline plasma NfL or T-tau and longitudinal neuroimaging changes. Models adjust for age, sex, education, and whether or not the cognitive test had been previously administered. WMH volume and infarct measurements were log-transformed. Hippocampal volume measures were adjusted for total intracranial volume. Median follow-up in the cohort was 6.2 years. Abbreviations: FA fractional anisotropy, NfL neurofilament light, T-tau total tau, WMH white matter hyperintensity

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