Skip to main content

Table 3 Evolution in memory outcomes according to plasma MCP-1 status

From: Plasma MCP-1 and changes on cognitive function in community-dwelling older adults

  Low plasma MCP-1a High plasma MCP-1 Between-group differenceb P value
Within-group evolution
Estimated mean (95% CI)c
Within-group evolution
Estimated mean (95% CI)
Estimated difference (95%CI)
FCSRT free recall,n= 1079
 12 months −1.28 (−1.66, −0.91) −1.93 (−3.00, −0.85) −0.65 (−1.73, 0.44) 0.243
 24 months −0.70 (−1.11, 0.30) −1.56 (−2.69, −0.44) −0.86 (−2.01, 0.29) 0.142
 36 months −1.56 (−2.03, −1.10) −2.82 (−4.03, −1.60) −1.25(−2.51, 0.01) 0.051
 48 months −1.82 (−2.33, −1.32) −3.24 (−4.52, −1.96) −1.42 (−2.76, −0.06) 0.039
FCSRT total recall,n= 1079
 12 months −0.76 (−0.98, −0.55) −1.63 (−2.22, −1.05) −0.87 (−1.46, −0.27) 0.004
 24 months −0.40 (−0.64, −0.16) −1.07 (−1.71, −0.44) −0.68 (−1.33, −0.02) 0.042
 36 months −1.16 (−1.45,−0.88) −1.81 (−2.52, −1.11) −0.65 (−1.40, −0.10) 0.089
 48 months −1.09 (−1.42, −0.77) −1.59 (−2.37, −0.82) −0.50 (−1.33, 0.33) 0.240
FCSRT free delayed recall,n= 1079
 12 months −0.13 (−0.30, 0.04) −0.60 (−0.96, −0.24) −0.47 (−0.84, −0.10) 0.090
 24 months −0.17 (−0.35, 0.01) −0.52 (−0.90, −0.15) −0.35 (−0.74, 0.04) 0.206
 36 months 0.32 (0.52,0.11) 0.82 (1.23,0.41) 0.50 (0.04,0.07) 0.045
 48 months 0.54 (0.75,0.32) 1.06 (149,0.63) 0.52 (0.98,0.06) 0.024
FCSRT total delayed recall,n= 1079
 12 months 0.10 (0.18, 0.02) 0.34 (0.53,0.15) 0.24 (0.44,0.05) 0.014
 24 months 0.10 (0.19,0.02) 0.38 (0.59,0.17) 0.28 (0.50,0.05) 0.015
 36 months −0.32 (−0.42, −0.21) −0.46 (−0.71, −0.22) −0.15 (−0.41, 0.12) 0.284
 48 months 0.35 (0.47,0.23) 0.77 (1.05,0.49) 0.42 (0.72,0.12) 0.007
  1. Significant associations in bold. Models were adjusted by sex, age, BMI, MAPT group, CDR status at baseline, GDS score, and ApoE ε4 genotype
  2. Abbreviations: MCP-1 Monocyte Chemoattractant Protein-1, FCSRT Free and Cued Selective Reminding Test
  3. aHigh MCP-1 defined as values in the 4th quartile (> 251 pg/mL)
  4. bNegative values for within-group differences mean cognitive decline
  5. cNegative values for between-group differences indicate more pronounced cognitive decline among the high plasma MCP-1 group