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Table 3 Evolution in memory outcomes according to plasma MCP-1 status

From: Plasma MCP-1 and changes on cognitive function in community-dwelling older adults

 

Low plasma MCP-1a

High plasma MCP-1

Between-group differenceb

P value

Within-group evolution

Estimated mean (95% CI)c

Within-group evolution

Estimated mean (95% CI)

Estimated difference (95%CI)

FCSRT free recall,n= 1079

 12 months

−1.28 (−1.66, −0.91)

−1.93 (−3.00, −0.85)

−0.65 (−1.73, 0.44)

0.243

 24 months

−0.70 (−1.11, 0.30)

−1.56 (−2.69, −0.44)

−0.86 (−2.01, 0.29)

0.142

 36 months

−1.56 (−2.03, −1.10)

−2.82 (−4.03, −1.60)

−1.25(−2.51, 0.01)

0.051

 48 months

−1.82 (−2.33, −1.32)

−3.24 (−4.52, −1.96)

−1.42 (−2.76, −0.06)

0.039

FCSRT total recall,n= 1079

 12 months

−0.76 (−0.98, −0.55)

−1.63 (−2.22, −1.05)

−0.87 (−1.46, −0.27)

0.004

 24 months

−0.40 (−0.64, −0.16)

−1.07 (−1.71, −0.44)

−0.68 (−1.33, −0.02)

0.042

 36 months

−1.16 (−1.45,−0.88)

−1.81 (−2.52, −1.11)

−0.65 (−1.40, −0.10)

0.089

 48 months

−1.09 (−1.42, −0.77)

−1.59 (−2.37, −0.82)

−0.50 (−1.33, 0.33)

0.240

FCSRT free delayed recall,n= 1079

 12 months

−0.13 (−0.30, 0.04)

−0.60 (−0.96, −0.24)

−0.47 (−0.84, −0.10)

0.090

 24 months

−0.17 (−0.35, 0.01)

−0.52 (−0.90, −0.15)

−0.35 (−0.74, 0.04)

0.206

 36 months

−0.32 (−0.52, −0.11)

−0.82 (−1.23, −0.41)

−0.50 (−0.04, −0.07)

0.045

 48 months

−0.54 (−0.75, −0.32)

−1.06 (1−49, −0.63)

−0.52 (−0.98, −0.06)

0.024

FCSRT total delayed recall,n= 1079

 12 months

−0.10 (−0.18, 0.02)

−0.34 (−0.53, −0.15)

−0.24 (−0.44, −0.05)

0.014

 24 months

−0.10 (−0.19, −0.02)

−0.38 (−0.59, −0.17)

−0.28 (−0.50, −0.05)

0.015

 36 months

−0.32 (−0.42, −0.21)

−0.46 (−0.71, −0.22)

−0.15 (−0.41, 0.12)

0.284

 48 months

−0.35 (−0.47, −0.23)

−0.77 (−1.05, −0.49)

−0.42 (−0.72, −0.12)

0.007

  1. Significant associations in bold. Models were adjusted by sex, age, BMI, MAPT group, CDR status at baseline, GDS score, and ApoE ε4 genotype
  2. Abbreviations: MCP-1 Monocyte Chemoattractant Protein-1, FCSRT Free and Cued Selective Reminding Test
  3. aHigh MCP-1 defined as values in the 4th quartile (> 251 pg/mL)
  4. bNegative values for within-group differences mean cognitive decline
  5. cNegative values for between-group differences indicate more pronounced cognitive decline among the high plasma MCP-1 group