Skip to main content

Table 3 Evolution in memory outcomes according to plasma MCP-1 status

From: Plasma MCP-1 and changes on cognitive function in community-dwelling older adults

 

Low plasma MCP-1a

High plasma MCP-1

Between-group differenceb

P value

Within-group evolution

Estimated mean (95% CI)c

Within-group evolution

Estimated mean (95% CI)

Estimated difference (95%CI)

FCSRT free recall,n= 1079

 12 months

−1.28 (−1.66, −0.91)

−1.93 (−3.00, −0.85)

−0.65 (−1.73, 0.44)

0.243

 24 months

−0.70 (−1.11, 0.30)

−1.56 (−2.69, −0.44)

−0.86 (−2.01, 0.29)

0.142

 36 months

−1.56 (−2.03, −1.10)

−2.82 (−4.03, −1.60)

−1.25(−2.51, 0.01)

0.051

 48 months

−1.82 (−2.33, −1.32)

−3.24 (−4.52, −1.96)

−1.42 (−2.76, −0.06)

0.039

FCSRT total recall,n= 1079

 12 months

−0.76 (−0.98, −0.55)

−1.63 (−2.22, −1.05)

−0.87 (−1.46, −0.27)

0.004

 24 months

−0.40 (−0.64, −0.16)

−1.07 (−1.71, −0.44)

−0.68 (−1.33, −0.02)

0.042

 36 months

−1.16 (−1.45,−0.88)

−1.81 (−2.52, −1.11)

−0.65 (−1.40, −0.10)

0.089

 48 months

−1.09 (−1.42, −0.77)

−1.59 (−2.37, −0.82)

−0.50 (−1.33, 0.33)

0.240

FCSRT free delayed recall,n= 1079

 12 months

−0.13 (−0.30, 0.04)

−0.60 (−0.96, −0.24)

−0.47 (−0.84, −0.10)

0.090

 24 months

−0.17 (−0.35, 0.01)

−0.52 (−0.90, −0.15)

−0.35 (−0.74, 0.04)

0.206

 36 months

0.32 (0.52,0.11)

0.82 (1.23,0.41)

0.50 (0.04,0.07)

0.045

 48 months

0.54 (0.75,0.32)

1.06 (149,0.63)

0.52 (0.98,0.06)

0.024

FCSRT total delayed recall,n= 1079

 12 months

0.10 (0.18, 0.02)

0.34 (0.53,0.15)

0.24 (0.44,0.05)

0.014

 24 months

0.10 (0.19,0.02)

0.38 (0.59,0.17)

0.28 (0.50,0.05)

0.015

 36 months

−0.32 (−0.42, −0.21)

−0.46 (−0.71, −0.22)

−0.15 (−0.41, 0.12)

0.284

 48 months

0.35 (0.47,0.23)

0.77 (1.05,0.49)

0.42 (0.72,0.12)

0.007

  1. Significant associations in bold. Models were adjusted by sex, age, BMI, MAPT group, CDR status at baseline, GDS score, and ApoE ε4 genotype
  2. Abbreviations: MCP-1 Monocyte Chemoattractant Protein-1, FCSRT Free and Cued Selective Reminding Test
  3. aHigh MCP-1 defined as values in the 4th quartile (> 251 pg/mL)
  4. bNegative values for within-group differences mean cognitive decline
  5. cNegative values for between-group differences indicate more pronounced cognitive decline among the high plasma MCP-1 group