From: Plasma MCP-1 and changes on cognitive function in community-dwelling older adults
 | Low-plasma MCP-1a | High-plasma MCP-1 | Between-group differenceb | P value |
---|---|---|---|---|
Within-group evolution Estimated mean (95% CI)c | Within-group evolution Estimated mean (95% CI) | Estimated difference (95%CI) | ||
Cognitive Composite Scored,n= 1079 | ||||
 12 months | −0.06 (−0.15, 0.03) | −0.13 (−0.19, −0.08) | −0.08 (−0.17, 0.02) | 0.114 |
 24 months | −0.05 (−0.15, 0.04) | −0.18 (−0.18, −0.06) | −0.07 (−0.17, 0.03) | 0.196 |
 36 months | −0.14 (−0.24, −0.04) | −0.24 (−0.31, −0.17) | −0.10 (−0.21, 0.02) | 0.091 |
 48 months | −0.18 (−0.27, −0.08) | −0.31 (−0.39, −0.24) | −0.14 (−0.26, −0.02) | 0.023 |
MMSE,n= 1080 | ||||
 12 months | −0.04 (−0.30, −0.22) | −0.15 (−0.37, 0.07) | −0.11 (−0.38, 0.16) | 0.418 |
 24 months | −0.03 (−0.29, 0.23) | −0.16 (−0.39, 0.08) | −0.12 (−0.41, 0.16) | 0.386 |
 36 months | −0.21 (−0.48, 0.06) | −0.18 (−0.44, 0.08) | 0.03 (−0.29, 0.34) | 0.853 |
 48 months | −0.15 (−0.42, 0.13) | −0.30 (−0.57, −0.02) | −0.15 (−0.48, 0.18) | 0.382 |
CDR sum of boxes,n= 1080 | ||||
 12 months | 0.12 (0.07, 0.16) | 0.24 (0.15, 0.34) | 0.13 (0.03, 0.23) | 0.014 |
 24 months | 0.13 (0.07, 0.18) | 0.32 (0.20, 0.43) | 0.19 (0.06, 0.32) | 0.004 |
 36 months | 0.23 (0.16, 0.30) | 0.36 (0.22, 0.51) | 0.14 (−0.03, 0.30) | 0.098 |
 48 months | 0.34 (0.26, 0.41) | 0.52 (0.35, 0.69) | 0.18 (−0.01, 0.38) | 0.061 |
Executive function composite scoree,n= 1068 | ||||
 12 months | −0.03 (−0.07, 0.004) | −0.07 (−0.18, 0.04) | −0.04 (−0.15, 0.08) | 0.544 |
 24 months | −0.07 (−0.11, −0.03) | −0.11 (−0.23, 0.004) | −0.05 (−0.17, 0.07) | 0.452 |
 36 months | −0.12 (−0.17, −0.07) | −0.18 (−0.30, −0.05) | −0.06 (−0.19, 0.07) | 0.381 |
 48 months | −0.15 (−0.19, −0.10) | −0.21 (−0.34, −0.08) | −0.06 (−0.20, 0.08) | 0.379 |
Attention scoref,n= 1080 | ||||
 12 months | −0.03 (−0.07, 0.004) | −0.07 (−0.18, 0.04) | −0.04 (−0.15, 0.08) | 0.544 |
 24 months | −0.07 (−0.11, −0.03) | −0.11 (−0.23, 0.004) | −0.05 (−0.17, 0.07) | 0.452 |
 36 months | −0.12 (−0.17, −0.07) | −0.18 (−0.30, −0.05) | −0.06 (−0.19, 0.07) | 0.381 |
 48 months | −0.15 (−0.19, −0.10) | −0.21 (−0.34, −0.08) | −0.06 (−0.20, 0.08) | 0.379 |