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Table 4 Trial construct 2, N = 280 power performance by methods and scenarios with delta = 1.5, 1.85, 2.0, 2.5

From: Impact of potential modifications to Alzheimer’s disease clinical trials in response to disruption by COVID-19: a simulation study

N = 280 Effect size lme cat lme slp t test orig
Scenario 0 D = 1.5 .77 .75 .66 .66
D = 1.85 .90 .89 .82 .82
D = 2.0 .94 .92 .87 .87
D = 2.5 .99 .99 .97 .97
Scenario 1 D = 1.5 .32 .30 .15 .66
D = 1.85 .42 .40 .19 .82
D = 2.0 .46 .44 .22 .87
D = 2.5 .60 .62 .32 .97
Scenario 2 D = 1.5 .56 .51 .41 .66
D = 1.85 .71 .67 .56 .82
D = 2.0 .78 .74 .65 .87
D = 2.5 .92 .89 .82 .97
Scenario 3 D = 1.5 .59 .55 .46 .66
D = 1.85 .75 .71 .64 .82
D = 2.0 .81 .78 .72 .87
D = 2.5 .94 .92 .88 .97