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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Impact of potential modifications to Alzheimer’s disease clinical trials in response to disruption by COVID-19: a simulation study

Fig. 3

Simulation results by sample size and scenario for disease modification trials. There are three scenarios for three different approaches. The horizontal solid line (red) shows 0.80 power, and the vertical dashed line (red) indicates the 1.85-point difference in the ADAS-cog between treatment groups that the trial was originally powered to detect. The categorical time model (lme-cat, red), continuous time model (lme-slp, purple), and t tests (green) are presented. The blue curve shows the power of the t test under the original conditions with no impact of COVID-19 assumed

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