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Table 1 Baseline demographic, cognitive, and neuroimaging characteristics of study cohort

From: Baseline [18F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease

  CN
(n = 10)
Prodromal AD
(n = 26)
Mild AD
(n = 16)
Moderate AD
(n = 15)
p
Demographics      
 Age 67.2 (6.2) 69.8 (6.9) 71.9 (4.9) 70.8 (7.0) 0.31
 Sex (% male) 40% 46% 44% 53% 0.92
 Race/ethnicity (% non-Hispanic white) 90% 96% 81% 87% 0.47
 APOE status (% ε4+) 40% 78% 63% 93%a 0.023
MMSE      
 Baseline 29.2 (0.8) 28.0 (1.5) 26.0 (2.9)a,b 16.9 (2.8)a,b,c <0.001
 % complete 18-month data 90% 85% 75% 73% 0.65
 Average follow-up (days) 509.8 (122.9) 496.7 (128.9) 520.4 (82.0) 459.5 (141.9) 0.55
CDR-SB      
 Baseline 0.0 (0.2) 1.6 (0.8)a 3.3 (1.8)a,b 6.4 (1.9)a,b,c <0.001
 % complete 18-month data 90% 85% 75% 73% 0.65
 Average follow-up (days) 539.0 (124.3) 535.0 (127.2) 562.2 (76.6) 482.7 (181.4) 0.40
ADAS-Cog13      
 Baseline 9.3 (5.0) 14.8 (5.5) 22.1 (6.8)a,b 40.3 (6.9)a,b,c <0.001
 % complete 18-month data 90% 85% 75% 67% 0.43
 Average follow-up (days) 510.2 (123.1) 497.2 (129.2) 521.8 (83.4) 447.4 (142.3) 0.37
RBANS Total Index      
 Baseline 93.0 (10.8) 85.1 (11.8) 73.2 (14.8)a,b 55.8 (9.6)a,b,c <0.001
 % complete 18-month data 90% 85% 44%b 27%b <0.001
 Average follow-up (days) 510.2 (123.1) 497.2 (129.2) 421.2 (165.7) 361.2 (166.4)b 0.031
Neuroimaging      
 [18F]GTP1: WCG SUVR 1.12 (0.08) 1.18 (0.09)a 1.38 (0.26)a,b 1.55 (0.40)a,b <0.001
 [18F]florbetapir: cortical SUVR 1.18 (0.18) 1.37 (0.14)a 1.38 (0.12)a 1.41 (0.17)a 0.003
 MRI: cortical volume (cm3) 429.7 (39.4) 444.5 (39.7) 407.8 (31.0) 372.4 (77.4)a,b <0.001
  1. Data are expressed as means (SD). p-values refer to overall one-way ANOVA or chi-square tests. ap < 0.05 vs. CN; bp < 0.05 vs. prodromal AD; cp < 0.05 vs. mild AD. Abbreviations: CN, cognitively normal; MMSE, Mini-Mental State Examination; CDR-SB, Clinical Dementia Rating Sum of Boxes; ADAS-Cog13, 13-item version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; WCG, whole cortical gray; SUVR, standardized uptake value ratio