Fig. 2

The effect of IHT for 14 days with intervals of 14 days or 42 days in APP/PS1 mice. a Schematic representation of the experimental design. Six-month-old APP/PS1 mice with 14 days IHT followed by different interval times (14 days or 42 days) and then behavioral tests were performed. There was a significantly shorter escape latency at day 5 (b), shorter time in the first entry of the platform (c), and longer time spent in the goal quadrant (e) after 14 days IHT following 14 days of interval but not 42 days of interval compared to the control mice. However, there was no significant difference in the number of crossing over the platform location (d), distance in goal quadrant (f), and mean velocity (g) in both intervals of 14-day and 42-day groups. Control mice (n = 11), mice with IHT 14 days following interval of 14 days (n = 10) in mice with IHT 14 days following interval 42 days (n = 10); *p<0.05; **p < 0.01; ns, not significant