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Table 6 The results of the multiple linear regression analyses of the relationships between the serum zinc strata and Aβ retention in terms of APOE4 positivity

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

  Stratified zinc level
  Low Medium High
  B (95% CI) P B (95% CI) P  
APOE4-positive
 Model 1 0.184 (0.031 to 0.337) 0.020 0.021 (−0.130 to 0.171) 0.783 Reference
 Model 2 0.242 (0.079 to 0.406) 0.005 0.027 (−0.128 to 0.182) 0.721 Reference
APOE4-negative
 Model 1 0.032 (−0.016 to 0.080) 0.193 0.026 (−0.021 to 0.072) 0.274 Reference
 Model 2 0.040 (−0.010 to 0.091) 0.117 0.014 (−0.033 to 0.061) 0.551 Reference
  1. Abbreviations: beta-amyloid, APOE4 apolipoprotein ε4, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
  2. The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention values were used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, clinical diagnosis, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin