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Table 6 The results of the multiple linear regression analyses of the relationships between the serum zinc strata and Aβ retention in terms of APOE4 positivity

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

 

Stratified zinc level

 

Low

Medium

High

 

B (95% CI)

P

B (95% CI)

P

 

APOE4-positive

 Model 1

0.184 (0.031 to 0.337)

0.020

0.021 (−0.130 to 0.171)

0.783

Reference

 Model 2

0.242 (0.079 to 0.406)

0.005

0.027 (−0.128 to 0.182)

0.721

Reference

APOE4-negative

 Model 1

0.032 (−0.016 to 0.080)

0.193

0.026 (−0.021 to 0.072)

0.274

Reference

 Model 2

0.040 (−0.010 to 0.091)

0.117

0.014 (−0.033 to 0.061)

0.551

Reference

  1. Abbreviations: Aβ beta-amyloid, APOE4 apolipoprotein ε4, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
  2. The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention values were used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, clinical diagnosis, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin
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Alzheimer's Research & Therapy

ISSN: 1758-9193