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Table 5 The results of multiple linear regression analyses including interaction terms between the serum zinc strata and age (or sex, or APOE4 positivity, or the VRS, or the copper level) in terms of predicting Aβ retention

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

 

B (95% CI)a

P

Low zinc

0.056 (− 0.176 to 0.288)

0.636

Medium zinc

0.119 (−0.061 to 0.299)

0.193

Age

0.006 (0.003 to 0.009)

< 0.001

Low zinc × age

< 0.001 (−0.003 to 0.004)

0.913

Medium zinc × age

−0.001 (− 0.004 to 0.001)

0.250

Low zinc

0.047 (−0.020 to 0.114)

0.170

Medium zinc

0.029 (−0.035 to 0.093)

0.374

Sex

0.002 (− 0.063 to 0.067)

0.953

Low zinc × sex

0.055 (− 0.038 to 0.149)

0.247

Medium zinc × sex

−0.021 (− 0.111 to 0.068)

0.637

Low zinc

0.040 (−0.015 to 0.096)

0.152

Medium zinc

0.016 (− 0.036 to 0.067)

0.553

APOE4 positivity

−0.002 (− 0.086 to 0.082)

0.958

Low zinc × APOE4 positivity

0.162 (0.040 to 0.284)

0.010

Medium zinc × APOE4 positivity

0.030 (−0.089 to 0.148)

0.624

Low zinc

0.101 (0.029 to 0.174)

0.006

Medium zinc

0.051 (−0.015 to 0.117)

0.130

VRS

0.008 (−0.023 to 0.040)

0.607

Low zinc × VRS

−0.029 (− 0.080 to 0.022)

0.260

Medium zinc × VRS

−0.028 (− 0.071 to 0.015)

0.197

Low zinc

0.060 (−0.128 to 0.249)

0.530

Medium zinc

0.049 (−0.111 to 0.209)

0.547

Copper

< 0.001 (−0.002 to 0.002)

0.912

Low zinc × copper

< 0.001 (−0.002 to 0.002)

0.904

Medium zinc × copper

< 0.001 (−0.002 to 0.001)

0.699

Low zinc

0.049 (−0.222 to 0.320)

0.719

Medium zinc

0.112 (−0.101 to 0.324)

0.300

Calcium

0.050 (−0.022 to 0.122)

0.175

Low zinc × calcium

0.002 (−0.027 to 0.031)

0.877

Medium zinc × calcium

−0.010 (− 0.033 to 0.012)

0.365

Low zinc

0.019 (−0.120 to 0.158)

0.788

Medium zinc

0.059 (−0.066 to 0.184)

0.351

Iron

< 0.001 (< 0.001 to 0.001)

0.445

Low zinc × iron

< 0.001 (−0.001 to 0.002)

0.390

Medium zinc × iron

< 0.001 (−0.001 to 0.001)

0.451

  1. Abbreviations: APOE4 apolipoprotein ε4, VRS vascular risk score, beta-amyloid, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score
  2. aMultiple linear regression model included zinc, age (or sex or APOE4 positivity or VRS or copper or calcium or iron), and the interaction between zinc and age (or sex or APOE4 positivity or VRS or copper or calcium or iron) treated as the independent variables; for all potential confound factors were treated as covariates; and Aβ treated as the dependent variable