Skip to main content

Table 5 The results of multiple linear regression analyses including interaction terms between the serum zinc strata and age (or sex, or APOE4 positivity, or the VRS, or the copper level) in terms of predicting Aβ retention

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

  B (95% CI)a P
Low zinc 0.056 (− 0.176 to 0.288) 0.636
Medium zinc 0.119 (−0.061 to 0.299) 0.193
Age 0.006 (0.003 to 0.009) < 0.001
Low zinc × age < 0.001 (−0.003 to 0.004) 0.913
Medium zinc × age −0.001 (− 0.004 to 0.001) 0.250
Low zinc 0.047 (−0.020 to 0.114) 0.170
Medium zinc 0.029 (−0.035 to 0.093) 0.374
Sex 0.002 (− 0.063 to 0.067) 0.953
Low zinc × sex 0.055 (− 0.038 to 0.149) 0.247
Medium zinc × sex −0.021 (− 0.111 to 0.068) 0.637
Low zinc 0.040 (−0.015 to 0.096) 0.152
Medium zinc 0.016 (− 0.036 to 0.067) 0.553
APOE4 positivity −0.002 (− 0.086 to 0.082) 0.958
Low zinc × APOE4 positivity 0.162 (0.040 to 0.284) 0.010
Medium zinc × APOE4 positivity 0.030 (−0.089 to 0.148) 0.624
Low zinc 0.101 (0.029 to 0.174) 0.006
Medium zinc 0.051 (−0.015 to 0.117) 0.130
VRS 0.008 (−0.023 to 0.040) 0.607
Low zinc × VRS −0.029 (− 0.080 to 0.022) 0.260
Medium zinc × VRS −0.028 (− 0.071 to 0.015) 0.197
Low zinc 0.060 (−0.128 to 0.249) 0.530
Medium zinc 0.049 (−0.111 to 0.209) 0.547
Copper < 0.001 (−0.002 to 0.002) 0.912
Low zinc × copper < 0.001 (−0.002 to 0.002) 0.904
Medium zinc × copper < 0.001 (−0.002 to 0.001) 0.699
Low zinc 0.049 (−0.222 to 0.320) 0.719
Medium zinc 0.112 (−0.101 to 0.324) 0.300
Calcium 0.050 (−0.022 to 0.122) 0.175
Low zinc × calcium 0.002 (−0.027 to 0.031) 0.877
Medium zinc × calcium −0.010 (− 0.033 to 0.012) 0.365
Low zinc 0.019 (−0.120 to 0.158) 0.788
Medium zinc 0.059 (−0.066 to 0.184) 0.351
Iron < 0.001 (< 0.001 to 0.001) 0.445
Low zinc × iron < 0.001 (−0.001 to 0.002) 0.390
Medium zinc × iron < 0.001 (−0.001 to 0.001) 0.451
  1. Abbreviations: APOE4 apolipoprotein ε4, VRS vascular risk score, beta-amyloid, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score
  2. aMultiple linear regression model included zinc, age (or sex or APOE4 positivity or VRS or copper or calcium or iron), and the interaction between zinc and age (or sex or APOE4 positivity or VRS or copper or calcium or iron) treated as the independent variables; for all potential confound factors were treated as covariates; and Aβ treated as the dependent variable