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Table 2 The results of multiple linear regression analyses assessing the relationships between the serum zinc strata and the Aβ, AV-1451, AD-CM, and WMH status of cognitively normal older adults

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

 

Stratified zinc level

 

Low

Medium

High

 

B (95% CI)

P

B (95% CI)

P

 

Aβ retention, SUVR

 Model 1

0.064 (0.015 to 0.113)

0.011

0.025 (−0.022 to 0.073)

0.291

Reference

 Model 2

0.072 (0.022 to 0.123)

0.005

0.020 (−0.027 to 0.068)

0.398

Reference

AV-1451, SUVR

 Model 1

−0.020 (− 0.195 to 0.154)

0.817

−0.090 (− 0.277 to 0.097)

0.340

Reference

 Model 2

0.023 (−0.179 to 0.225)

0.819

−0.019 (− 0.233 to 0.195)

0.859

Reference

AD-CM, SUVR

 Model 1

−0.045 (− 0.083 to − 0.006)

0.025

− 0.024 (− 0.061 to 0.014)

0.213

Reference

 Model 2

−0.048 (− 0.091 to − 0.006)

0.024

− 0.020 (− 0.059 to 0.019)

0.317

Reference

WMH, cm3

 Model 1

−0.070 (− 0.381 to 0.241)

0.656

−0.012 (− 0.317 to 0.293)

0.939

Reference

 Model 2

−0.177 (− 0.504 to 0.149)

0.285

−0.089 (− 0.394 to 0.216)

0.567

Reference

  1. Abbreviations: beta-amyloid, AD-CM Alzheimer’s disease signature cerebral glucose metabolism, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
  2. The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention and WMH values were used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin