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Table 2 The results of multiple linear regression analyses assessing the relationships between the serum zinc strata and the Aβ, AV-1451, AD-CM, and WMH status of cognitively normal older adults

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

  Stratified zinc level
  Low Medium High
  B (95% CI) P B (95% CI) P  
Aβ retention, SUVR
 Model 1 0.064 (0.015 to 0.113) 0.011 0.025 (−0.022 to 0.073) 0.291 Reference
 Model 2 0.072 (0.022 to 0.123) 0.005 0.020 (−0.027 to 0.068) 0.398 Reference
AV-1451, SUVR
 Model 1 −0.020 (− 0.195 to 0.154) 0.817 −0.090 (− 0.277 to 0.097) 0.340 Reference
 Model 2 0.023 (−0.179 to 0.225) 0.819 −0.019 (− 0.233 to 0.195) 0.859 Reference
AD-CM, SUVR
 Model 1 −0.045 (− 0.083 to − 0.006) 0.025 − 0.024 (− 0.061 to 0.014) 0.213 Reference
 Model 2 −0.048 (− 0.091 to − 0.006) 0.024 − 0.020 (− 0.059 to 0.019) 0.317 Reference
WMH, cm3
 Model 1 −0.070 (− 0.381 to 0.241) 0.656 −0.012 (− 0.317 to 0.293) 0.939 Reference
 Model 2 −0.177 (− 0.504 to 0.149) 0.285 −0.089 (− 0.394 to 0.216) 0.567 Reference
  1. Abbreviations: beta-amyloid, AD-CM Alzheimer’s disease signature cerebral glucose metabolism, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
  2. The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention and WMH values were used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin