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Table 3 Least squares estimates of SAGE/MMSE score mean changes from baseline (V0) (p values) for visits V1–V9a

From: Self-Administered Gerocognitive Examination: longitudinal cohort testing for the early detection of dementia conversion

Subgroupb Test Visit number (average duration in months since baseline visit V0)
V1 (4.8) V2 (8.3) V3 (14.4) V4 (20.4) V5 (26.6) V6 (32.9) V7 (41.4) V8 (58.4) V9 (81.1)
MCI to AD dementia SAGE −0.68 (0.4593) −0.44 (0.5043) −1.88 (0.0016)c −1.61 (0.0158) −3.57d −4.32d −5.51d −8.47d −11.25d
MMSE −1.17 (0.1544) −0.24 (0.6862) −1.07 (0.0440) −1.89 (0.0015)c −2.87d −4.01d −4.96d −6.96d −9.92d
MCI to other dementia SAGE 0.70 (0.6427) −1.26 (0.1904) −2.59 (0.0051)c −4.39d −4.85d −5.77d −5.35d −9.10d −14.33d
MMSEe −1.27 (0.3663) −0.85 (0.3749) −2.56 (0.0061) −2.02 (0.0528) −2.87 (0.0072) −3.97 (0.0005)c −3.48 (0.0005) −7.15d −15.94d
AD dementia SAGE −0.85 (0.0406) −1.09 (0.0001)c −2.22d −3.17d −3.77d −5.27d −5.85d −7.26d −9.46d
MMSE −0.17 (0.7150) −0.77 (0.0195) −2.23c,d −3.29d −5.34d −5.94d −6.48d −8.52d −11.34d
  1. Abbreviations: AD Alzheimer’s disease, MCI Mild cognitive impairment, MMSE Mini-Mental State Examination, SAGE Self-Administered Gerocognitive Examination, SCD Subjective cognitive decline
  2. aVisit Numbers V1-V9 are labeled as V1: within 6 months; V2: 6–12 months; V3: 12–18 months, V4: 18–24 months, V5: 24–30 months, V6: 30–36 months, V7: 36–48 months, V8: 48–72 months, V9: over 72 months (max 105 months)
  3. bNone of the mean differences in the MCI (non-converter) and SCD groups was significant
  4. cFirst significant difference; threshold for significance with Bonferroni correction is a p value below 0.05/9 = 0.00555
  5. dRepresents p values under 0.0001
  6. eOne outlier removed