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Effects of p-tau severity on atrophy
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|---|
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Measures of atrophy
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Standardized beta
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Standard error
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P-value
|
|---|
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aVisually rated MRI global atrophy
|
0.68
|
0.22
|
<0.01
|
|
Frontal lobes
|
0.30
|
0.15
|
0.047
|
|
Temporal lobes
|
0.23
|
0.15
|
0.15
|
|
Posterior lobes
|
0.08
|
0.15
|
0.62
|
|
Medial temporal lobes
|
0.25
|
0.21
|
0.25
|
- A summary composite of semi-quantitative ratings of p-tau (0 [none]–3 [severe] scale) across 14 cortical and subcortical brain regions was computed7 and served as the independent variable. A global composite of MRI atrophy was calculated, based on the sum of frontal (orbital-frontal cortex, dorsolateral frontal cortex, superior frontal cortex), anterior temporal, posterior (parietal, occipital), and MTL visual MRI ratings of atrophy. P-tau severity was assessed in the following regions that mapped onto lobes visually rated for atrophy on MRI: frontal cortex (dorsolateral frontal cortex + inferior frontal cortex), superior temporal cortex, inferior parietal cortex, and hippocampus (CA1+CA2+CA4)
- aThe primary analyses included linear regression models that tested the association between global-based composites to limit the number of analyses and to increase statistical power. Exploratory linear regression analyses examined regional correspondence between p-tau severity and the MRI ratings of atrophy. Analyses controlled for age at death and time since MRI
