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Table 5 Summary of regression models examining the effect of P-tau severity on atrophy in the brain donors with CTE

From: Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE

  Effects of p-tau severity on atrophy
Measures of atrophy Standardized beta Standard error P-value
aVisually rated MRI global atrophy 0.68 0.22 <0.01
 Frontal lobes 0.30 0.15 0.047
 Temporal lobes 0.23 0.15 0.15
 Posterior lobes 0.08 0.15 0.62
 Medial temporal lobes 0.25 0.21 0.25
  1. A summary composite of semi-quantitative ratings of p-tau (0 [none]–3 [severe] scale) across 14 cortical and subcortical brain regions was computed7 and served as the independent variable. A global composite of MRI atrophy was calculated, based on the sum of frontal (orbital-frontal cortex, dorsolateral frontal cortex, superior frontal cortex), anterior temporal, posterior (parietal, occipital), and MTL visual MRI ratings of atrophy. P-tau severity was assessed in the following regions that mapped onto lobes visually rated for atrophy on MRI: frontal cortex (dorsolateral frontal cortex + inferior frontal cortex), superior temporal cortex, inferior parietal cortex, and hippocampus (CA1+CA2+CA4)
  2. aThe primary analyses included linear regression models that tested the association between global-based composites to limit the number of analyses and to increase statistical power. Exploratory linear regression analyses examined regional correspondence between p-tau severity and the MRI ratings of atrophy. Analyses controlled for age at death and time since MRI