Fig. 4

MRI and autopsy patterns of atrophy and P-tau deposition in a brain donor with CTE. The figure shows an antemortem axial (A) and coronal (D) T1 MRI sequence and corresponding gross atrophy at autopsy (B, C, E) of a male former professional American football player with CTE stage IV. The antemortem MRI scan was done when he was in his early 60’s and he died in his mid-70s and donated his brain. The antemortem MRI and neuropathological examination both showed frontal and temporal cortical atrophy (A–E) along with atrophy of medial temporal lobe structures (C, E) including the hippocampus and amygdala