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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases

Fig. 5

Summary representation of dopaminergic dysfunction in early AD. Brain renderings show dopaminergic targets presenting with decreased DAT activity (orange), loss of molecular connectivity (yellow), or both (red) in prodromal AD. Alterations in these target regions can be deemed indicative of pre-synaptic dopaminergic dysfunction in specific afferents from the ventral and dorsal VTA and from the medial SN, pars compacta. For the purpose of ensuring a clear visualization, dopaminergic projections are represented only for each target region on the ipsilateral side. Brain renderings were obtained from the BrainNet Viewer toolbox [35]. Abbreviations: SNc, substantia nigra pars compacta; VTA, ventral tegmental area

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Alzheimer's Research & Therapy

ISSN: 1758-9193