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Table 2 Summary of sample characteristics

From: Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Sample

CN

MCI

AD

ADNI-GO/2 (training) N = 663

 Sample size (female)

254 (130)

220 (93)

189 (80)

 Age (SD)

75.4 (6.6)

74.1 (8.1)

75.0 (8.0)

 Education (SD)

16.4 (2.7)

16.2 (2.8)

15.9 (2.7)

 MMSE (SD)

29.1 (1.2)

27.6 (1.9)

22.6 (3.2)

 RAVLT Delayed recall (SD)

7.6 (4.1)

3.2 (3.7)

0.8 (1.9)

 WMS-LM Delayed recall (SD)

13.9 (3.7)

5.1 (3.8)

1.5 (2.1)

 Hippocampus volume (SD) mm3

6235 (756)

5619 (963)

4834 (930)

 Amyloid status (neg/pos)

177/77

79/141

28/161

MRI field strength (1.5T/3T)

71/183

49/171

35/154

ADNI-3 (validation) N = 575

 Sample size (female)

326 (211)

187 (85)

62 (27)

 Age (SD)

70.0 (7.5)

72.2 (7.5)

74.8 (7.7)

 Education (SD)

16.6 (2.2)

16.6 (2.5)

16.5 (2.4)

 MMSE (SD)

29.1 (1.1)

27.8 (2.0)

23.1 (3.3)

 RAVLT Delayed recall (SD)

8.3 (4.4)

4.7 (4.7)

0.3 (0.9)

 WMS-LM Delayed recall (SD)

13.0 (3.5)

7.2 (3.9)

2.0 (2.8)

 Hippocampus volume (SD) mm3

6583 (649)

6112 (902)

4839 (978)

 Amyloid status (neg/pos)

75/39

19/27

3/17

 MRI field strength (1.5T/3T)

0/326

0/187

0/62

AIBL (validation) N = 606

 Sample size (female)

448 (260)

96 (46)

62 (36)

 Age (SD)

72.4 (6.2)

74.3 (6.9)

73.2 (7.3)

 MMSE (SD)

28.7 (1.2)

27.0 (2.2)

21.2 (5.3)

 WMS-LM Delayed recall (SD)

11.2 (4.3)

4.9 (4.0)

1.0 (1.9)

 Hippocampus volume (SD) mm3

6362 (704)

5712 (1028)

4940 (1055)

 Amyloid status (neg/pos)

316/101

34/54

6/53

 MRI field strength (1.5T/3T)

55/393

7/89

2/60

DELCODE (validation) N = 474

 Sample size (female)

215 (124)

155 (72)

104 (61)

 Age (SD)

69.5 (5.5)

73.0 (5.7)

75.2 (6.2)

 Education (SD)

14.7 (2.7)

14.0 (3.1)

12.9 (3.1)

 MMSE (SD)

29.5 (0.8)

27.8 (2.0)

23.1 (3.2)

 WMS-LM Delayed recall (SD)

14.3 (3.6)

7.4 (5.2)

1.8 (2.8)

 Hippocampus volume (SD) mm3

6543 (679)

5665 (950)

4610 (944)

 Amyloid status (neg/pos)

58/28

30/57

5/49

 MRI field strength (1.5T/3T)

0/215

0/155

0/104

  1. Numbers indicate mean and standard deviation (SD) if not indicated otherwise. Years of education were not available for the AIBL dataset. RAVLT Delayed recall scores were not available for the AIBL and DELCODE samples
  2. CN cognitively normal controls, MCI amnestic mild cognitive impairment, AD Alzheimer’s dementia, SD standard deviation, MMSE Mini Mental State Examination, RAVLT Rey Auditory Verbal Learning Test, WMS-LM Wechsler Memory Scale Logical Memory Test, MRI magnetic resonance imaging