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Table 2 Summary of sample characteristics

From: Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Sample CN MCI AD
ADNI-GO/2 (training) N = 663
 Sample size (female) 254 (130) 220 (93) 189 (80)
 Age (SD) 75.4 (6.6) 74.1 (8.1) 75.0 (8.0)
 Education (SD) 16.4 (2.7) 16.2 (2.8) 15.9 (2.7)
 MMSE (SD) 29.1 (1.2) 27.6 (1.9) 22.6 (3.2)
 RAVLT Delayed recall (SD) 7.6 (4.1) 3.2 (3.7) 0.8 (1.9)
 WMS-LM Delayed recall (SD) 13.9 (3.7) 5.1 (3.8) 1.5 (2.1)
 Hippocampus volume (SD) mm3 6235 (756) 5619 (963) 4834 (930)
 Amyloid status (neg/pos) 177/77 79/141 28/161
MRI field strength (1.5T/3T) 71/183 49/171 35/154
ADNI-3 (validation) N = 575
 Sample size (female) 326 (211) 187 (85) 62 (27)
 Age (SD) 70.0 (7.5) 72.2 (7.5) 74.8 (7.7)
 Education (SD) 16.6 (2.2) 16.6 (2.5) 16.5 (2.4)
 MMSE (SD) 29.1 (1.1) 27.8 (2.0) 23.1 (3.3)
 RAVLT Delayed recall (SD) 8.3 (4.4) 4.7 (4.7) 0.3 (0.9)
 WMS-LM Delayed recall (SD) 13.0 (3.5) 7.2 (3.9) 2.0 (2.8)
 Hippocampus volume (SD) mm3 6583 (649) 6112 (902) 4839 (978)
 Amyloid status (neg/pos) 75/39 19/27 3/17
 MRI field strength (1.5T/3T) 0/326 0/187 0/62
AIBL (validation) N = 606
 Sample size (female) 448 (260) 96 (46) 62 (36)
 Age (SD) 72.4 (6.2) 74.3 (6.9) 73.2 (7.3)
 MMSE (SD) 28.7 (1.2) 27.0 (2.2) 21.2 (5.3)
 WMS-LM Delayed recall (SD) 11.2 (4.3) 4.9 (4.0) 1.0 (1.9)
 Hippocampus volume (SD) mm3 6362 (704) 5712 (1028) 4940 (1055)
 Amyloid status (neg/pos) 316/101 34/54 6/53
 MRI field strength (1.5T/3T) 55/393 7/89 2/60
DELCODE (validation) N = 474
 Sample size (female) 215 (124) 155 (72) 104 (61)
 Age (SD) 69.5 (5.5) 73.0 (5.7) 75.2 (6.2)
 Education (SD) 14.7 (2.7) 14.0 (3.1) 12.9 (3.1)
 MMSE (SD) 29.5 (0.8) 27.8 (2.0) 23.1 (3.2)
 WMS-LM Delayed recall (SD) 14.3 (3.6) 7.4 (5.2) 1.8 (2.8)
 Hippocampus volume (SD) mm3 6543 (679) 5665 (950) 4610 (944)
 Amyloid status (neg/pos) 58/28 30/57 5/49
 MRI field strength (1.5T/3T) 0/215 0/155 0/104
  1. Numbers indicate mean and standard deviation (SD) if not indicated otherwise. Years of education were not available for the AIBL dataset. RAVLT Delayed recall scores were not available for the AIBL and DELCODE samples
  2. CN cognitively normal controls, MCI amnestic mild cognitive impairment, AD Alzheimer’s dementia, SD standard deviation, MMSE Mini Mental State Examination, RAVLT Rey Auditory Verbal Learning Test, WMS-LM Wechsler Memory Scale Logical Memory Test, MRI magnetic resonance imaging