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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: The apolipoprotein receptor LRP3 compromises APP levels

Fig. 7

Inhibition of lysosomal/autophagy function increases APP and sAPP levels. Western blots and quantification of CHO-PS70 cells transfected with LRP3-flag (CHO LRP3) or pcDNA3.1 (CHO) for 24h and then treated with 10 mM chloroquine (CQ) for another 24 h or with vehicle (veh, Hank’s media). Western blots show the expression in the cell extracts of LRP3, full-length APP (fAPP), and tubulin, and the expression of sAPPα and sAPPβ from the supernatants (n = 6–14 for each condition, **p<0.01 for fAPP respect to control; **p<0.05 for sAPPα respect to control; p = 0.065 for sAPPβ)

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