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Table 2 Biological pathways identified in the enrichment analysis

From: Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease

Category

Pathway

Overlap

P-value

FDR-corrected P-value

Odds ratio

Gene

Biological process

Protein oligomerization

2/217

2.37 × 10−3

7.81 × 10− 3

26.33

FCER1G, TRIM4

Positive regulation of programmed cell death

2/257

3.31 × 10−3

7.81 × 10− 3

22.23

APH1B, BIN1

Positive regulation of the apoptotic process

2/307

4.69 × 10−3

7.81 × 10− 3

18.61

APH1B, BIN1

Vesicle-mediated transport

2/410

8.22 × 10−3

1.03 × 10−2

13.94

BIN1, RABEP

Regulation of the apoptotic process

2/815

3.04 × 10−2

3.04 × 10− 2

7.01

APH1B, BIN1

Molecular function

Protein homodimerization activity

2/664

2.07 × 10−2

2.07 × 10− 2

8.61

FCER1G, RABEP1

  1. Overlap means a ratio of the number of input genes to the number of genes associated with each biological pathway. P-values and odds ratios were obtained from Fisher’s exact test
  2. Abbreviation: FDR false discovery rate