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Table 2 Biological pathways identified in the enrichment analysis

From: Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease

Category Pathway Overlap P-value FDR-corrected P-value Odds ratio Gene
Biological process Protein oligomerization 2/217 2.37 × 10−3 7.81 × 10− 3 26.33 FCER1G, TRIM4
Positive regulation of programmed cell death 2/257 3.31 × 10−3 7.81 × 10− 3 22.23 APH1B, BIN1
Positive regulation of the apoptotic process 2/307 4.69 × 10−3 7.81 × 10− 3 18.61 APH1B, BIN1
Vesicle-mediated transport 2/410 8.22 × 10−3 1.03 × 10−2 13.94 BIN1, RABEP
Regulation of the apoptotic process 2/815 3.04 × 10−2 3.04 × 10− 2 7.01 APH1B, BIN1
Molecular function Protein homodimerization activity 2/664 2.07 × 10−2 2.07 × 10− 2 8.61 FCER1G, RABEP1
  1. Overlap means a ratio of the number of input genes to the number of genes associated with each biological pathway. P-values and odds ratios were obtained from Fisher’s exact test
  2. Abbreviation: FDR false discovery rate