Table 7 Top 10 most frequently targeted AD genes, pathways, and mutational phenotypes by top-ranked (top 20% or top 44) microglia-associated microbial metabolites. The numbers of microbial metabolites were shown in the parenthesis
Top 10 AD genes associated with microbial metabolites | Top 10 AD pathways associated with microbial metabolites | Top 10 AD phenotypes associated with microbial metabolites |
|---|---|---|
APP (21), NOS (16), VEGFA (12), TNF (9), TF (8), MPO (6), PLAU (3), APOE (2), ACE (2), BLMH (2) | Hemostasis (28), Glypican 1 network (24), response to elevated platelet cytosolic Ca2+ (24), platelet activation, signaling and aggregation (24), Alzheimer’s disease (22), amyloids (21), deregulation of CDK5 in Alzheimer’s disease (21), innate immune system (21), VEGF signaling pathway (21), inflammasomes (21) | Abnormal synaptic transmission (27), abnormal long-term potentiation (27), gliosis (24), astrocytosis (24), amyloidosis (22), amyloid beta deposits (22), microgliosis (21), tau protein deposits (21), neuron degeneration (13), cerebral amyloid angiopathy (2) |