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Table 7 Top 10 most frequently targeted AD genes, pathways, and mutational phenotypes by top-ranked (top 20% or top 44) microglia-associated microbial metabolites. The numbers of microbial metabolites were shown in the parenthesis

From: Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Top 10 AD genes associated with microbial metabolites Top 10 AD pathways associated with microbial metabolites Top 10 AD phenotypes associated with microbial metabolites
APP (21), NOS (16), VEGFA (12), TNF (9), TF (8), MPO (6), PLAU (3), APOE (2), ACE (2), BLMH (2) Hemostasis (28), Glypican 1 network (24), response to elevated platelet cytosolic Ca2+ (24), platelet activation, signaling and aggregation (24), Alzheimer’s disease (22), amyloids (21), deregulation of CDK5 in Alzheimer’s disease (21), innate immune system (21), VEGF signaling pathway (21), inflammasomes (21) Abnormal synaptic transmission (27), abnormal long-term potentiation (27), gliosis (24), astrocytosis (24), amyloidosis (22), amyloid beta deposits (22), microgliosis (21), tau protein deposits (21), neuron degeneration (13), cerebral amyloid angiopathy (2)