Table 4 Rankings of the 22 AD-associated genes among the list of 23,995 prioritized genes when the input phenotypes “abnormal microglial cell morphology,” “abnormal microglial cell physiology,” and “microgliosis” were used separately or combined. A mean value of top 10.59% means that on average the 22 AD genes ranked in the top 10.59% among the prioritized list of 22,982 genes, which was significantly higher than the expected ranking of 50% based on random ranking
Input | Mean (top %) | Median (top %) | P-value |
|---|---|---|---|
Abnormal microglial cell physiology | 10.59 | 5.31 | 3.41E−11 |
Abnormal microglial cell morphology | 11.30 | 7.30 | 1.92E−11 |
Microgliosis | 113.1 | 9.48 | 3.39E−10 |
Combined | 11.49 | 7.81 | 6.47E−11 |