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Table 4 Rankings of the 22 AD-associated genes among the list of 23,995 prioritized genes when the input phenotypes “abnormal microglial cell morphology,” “abnormal microglial cell physiology,” and “microgliosis” were used separately or combined. A mean value of top 10.59% means that on average the 22 AD genes ranked in the top 10.59% among the prioritized list of 22,982 genes, which was significantly higher than the expected ranking of 50% based on random ranking

From: Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Input Mean (top %) Median (top %) P-value
Abnormal microglial cell physiology 10.59 5.31 3.41E−11
Abnormal microglial cell morphology 11.30 7.30 1.92E−11
Microgliosis 113.1 9.48 3.39E−10
Combined 11.49 7.81 6.47E−11