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Table 2 Known AD risk genes, core mouse phenotypes, and microbial metabolites that were used to evaluate the context-sensitive network-based prioritization algorithm

From: Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Evaluation dataset 1 (AD risk genes) Evaluation dataset 2 (AD phenotypes in mouse) Evaluation dataset 3 (AD microbial metabolites)
A2M, ABCA7, ACE, ADAM10, APBB2, APOE, APP, BLMH, HFE, MPO, MT-ND1, NOS3, PAXIP1, PLAU, PLD3, PRNP, PSEN1, PSEN2, SORL1, TF, TNF, VEGFA Amyloid beta deposits, amyloidosis
Cerebral amyloid angiopathy
Neurofibrillary tangles
Tau protein deposits
Neurodegeneration
Neuron degeneration
Gliosis
Astrocytosis
Microgliosis
Abnormal synaptic transmission
Abnormal long-term potentiation
Abnormal long-term depression
3,4-Dihydroxybenzeneacetic acid
3-Hydroxybutyric acid
Acetylcholine
d-Glutamic acid
Dopamine
Folic acid
Gamma-aminobutyric acid
l-Lactic acid
Mannitol
Putrescine
Pyruvic acid
Succinic acid