Table 2 Known AD risk genes, core mouse phenotypes, and microbial metabolites that were used to evaluate the context-sensitive network-based prioritization algorithm
Evaluation dataset 1 (AD risk genes) | Evaluation dataset 2 (AD phenotypes in mouse) | Evaluation dataset 3 (AD microbial metabolites) |
|---|---|---|
A2M, ABCA7, ACE, ADAM10, APBB2, APOE, APP, BLMH, HFE, MPO, MT-ND1, NOS3, PAXIP1, PLAU, PLD3, PRNP, PSEN1, PSEN2, SORL1, TF, TNF, VEGFA | Amyloid beta deposits, amyloidosis Cerebral amyloid angiopathy Neurofibrillary tangles Tau protein deposits Neurodegeneration Neuron degeneration Gliosis Astrocytosis Microgliosis Abnormal synaptic transmission Abnormal long-term potentiation Abnormal long-term depression | 3,4-Dihydroxybenzeneacetic acid 3-Hydroxybutyric acid Acetylcholine d-Glutamic acid Dopamine Folic acid Gamma-aminobutyric acid l-Lactic acid Mannitol Putrescine Pyruvic acid Succinic acid |