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Table 1 Overview of group size (n), age, weight, injected activity, injected mass, and molar activity for [11C]PiB and [18F]THK-5317 PET imaging

From: Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling

[11C]PiB n Age (months) Weight (g) Inj. Activity (MBq) Inj. Mass (nmol/kg) Molar activity (GBq/μmol)
Female APP/hTau 3 6.7 ± 0.3 257.7 ± 32.7 23.6 ± 6.1 3.2 ± 1.2 29.9 ± 5.0
Male APP/hTau 3 7.1 ± 0.1 493.0 ± 51.4 26.3 ± 0.7 6.1 ± 4.1 16.2 ± 16.8
Female APP/hTau 8 12.1 ± 0.6 334.5 ± 30.8 14.8 ± 2.2 0.4 ± 0.1 115.1 ± 12.9
Male APP/hTau 10 12.4 ± 0.7 540.6 ± 47.6 16.7 ± 3.3 0.3 ± 0.0 109.3 ± 22.7
Female APP/hTau 8 20.5 ± 0.5 347.0 ± 48.8 21.1 ± 1.1 0.6 ± 0.2 21.1 ± 1.1
Male APP/hTau 10 20.6 ± 0.3 606.9 ± 43.8 31.0 ± 16.8 0.5 ± 0.3 31.0 ± 16.8
[18F]THK-5317 n Age (months) Weight (g) Inj. Activity (MBq) Inj. Mass (nmol/kg) Molar activity (GBq/μmol)
Female ntg 6 7.0 ± 0.2 273.3 ± 17.6 19.2 ± 5.2 1.5 ± 0.6 52.5 ± 16.7
Female APP/hTau 7 7.0 ± 0.4 263.4 ± 21.2 17.8 ± 3.1 1.4 ± 1.7 149.9 ± 122.8
Male ntg 6 7.1 ± 0.1 491.2 ± 57.5 16.2 ± 3.8 0.7 ± 0.1 53.7 ± 15.2
Male APP/hTau 7 7.1 ± 0.3 485.6 ± 65.8 17.4 ± 3.8 0.3 ± 0.1 182.0 ± 118.6
Female ntg 6 12.8 ± 0.5 300.3 ± 38.0 15.0 ± 1.5 0.9 ± 0.5 71.3 ± 45.1
female APP/hTau 11 12.5 ± 0.5 319.7 ± 28.7 11.6 ± 4.3 0.7 ± 0.6 83.6 ± 66.3
Male ntg 2 13.4 ± 0.4 632.5 ± 0.7 8.8 ± 3.9 0.4 ± 0.5 194.8 ± 257.6
male APP/hTau 10 12.9 ± 0.4 520.3 ± 53.4 15.9 ± 4.3 0.4 ± 0.3 135.4 ± 99.1
Female ntg 4 20.7 ± 0.4 354.0 ± 82.9 18.5 ± 2.6 0.9 ± 1.0 103.1 ± 46.1
Female APP/hTau 6 20.7 ± 0.6 342.8 ± 52.1 16.2 ± 1.2 0.2 ± 0.1 388.9 ± 236.8
Male ntg 4 21.0 ± 0.3 538.3 ± 54.4 16.3 ± 2.5 0.6 ± 0.5 88.0 ± 70.8
Male APP/hTau 10 20.9 ± 0.3 594.5 ± 48.9 15.2 ± 2.6 0.2 ± 0.3 181.4 ± 112.6