Fig. 3
[11C]PiB binding potential (BPND) obtained with the simplified reference tissue model (SRTM) in central (A) and cortical (B) brain regions of APP/Tau rats pertaining to different age groups (circles: 7 months, n = 6; triangles: 13 months, n = 11; squares: 21 months, n = 12). Male and female animals were grouped, and only amyloid-positive animals based on immunofluorescent labeling analysis were included. Som.sen. Cortex = somatosensory cortex. * p < 0.05, one-way ANOVA followed by Tukey’s multiple comparisons test