Fig. 3
From: Age, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults
Associations of elevated tau, hypometabolism, hippocampal atrophy, and longitudinal cognitive decline in Aβ- individuals. Prediction of ΔPACC by baseline A CSF p-Tau/Aβ40, B FDG SUVR, and C aHCV. D Pathways between CSF p-Tau/Aβ40, FDG SUVR, and ΔPACC. E Pathways between CSF p-Tau/Aβ40, aHCV, and ΔPACC. Abbreviations: Aβ amyloid-β, aHCV adjusted hippocampal volume, CSF cerebrospinal fluid, CU cognitively unimpaired, CI cognitively impaired, FDG 18F-fluorodeoxyglucose, PACC Preclinical Alzheimer Cognitive Composite, p-Tau phosphorylated tau, SUVR standardized uptake value ratio