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Table 3 Models with different combinations of variables

From: Performance of the plasma Aβ42/Aβ40 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort

  Model 10-fold cross-validation in AD continuum Validation in the SVCI group
Model 1 Age 0.506 (0.407, 0.512) 0.643 (0.485, 0.8)
Model 2 APOE4 0.723 (0.614, 0.717) 0.59 (0.475, 0.705)
Model 3 Age + APOE4 0.727 (0.652, 0.751) 0.699 (0.558, 0.839)
Model 4 Aβ42/Aβ40 0.818 (0.76, 0.847) 0.823 (0.702, 0.944)
Model 5 APOE4 + Aβ42/Aβ40 0.858 (0.799, 0.876) 0.775 (0.646, 0.905)
Model 6 Age + APOE4 + Aβ42/Aβ40 0.855 (0.797, 0.875) 0.777 (0.648, 0.905)
Model 7 Age + APOE4 + Aβ42/Aβ40 + diagnosis 0.916 (0.877, 0.934) NA
  1. Values are presented as AUC (95% confidence interval for AUC). Except for model 2 vs. model 3 (p = 0.661) and model 5 vs. model 6 (p = 0.791), all two individual models showed statistically different AUC values (all p < 0.05)
  2. AUC area under the receiver operating characteristic curve