Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum

Table 2 Group difference in neuropsychological test scores

	A-/T-^a	A+/T-^b	A+/T+^c	p value	Post hoc
Psychomotor speed
TMT A	37.51 ± 2.60	31.40 ± 5.00	39.50 ± 3.24	0.395	n.s
Attention
DSF	5.41 ± 0.14	5.67 ± 0.27	5.76 ± 0.17	0.278	n.s
DSB	3.22 ± 0.10	3.67 ± 0.19	3.45 ± 0.12	0.083	n.s
Language
BNT	43.63 ± 0.98	45.29 ± 1.91	42.62 ± 1.22	0.497	n.s
Visuospatial function
RCFT copy	31.02 ± 0.62	33.14 ± 1.20	28.75 ± 0.75	0.006	b > c
Memory
SVLT imm	17.20 ± 0.46	15.71 ± 0.89	15.12 ± 0.55	0.020	a > c
SVLT delayed	4.81 ± 0.22	3.29 ± 0.43	2.71 ± 0.27	1.5E− 7^†	a > b, c
SVLT rec	19.90 ± 0.25	19.26 ± 0.48	17.87 ± 0.30	1.1E− 5^†	a, b > c
LM I	15.04 ± 0.65	13.50 ± 1.54	12.25 ± 1.41	0.200	n.s
LM II	10.43 ± 0.68	9.38 ± 1.60	8.02 ± 1.46	0.343	n.s
LM rec	19.25 ± 0.51	17.54 ± 1.20	16.51 ± 1.09	0.070	n.s
RCFT imm	13.71 ± 0.66	12.56 ± 1.27	6.22 ± 0.79	2.8E− 10^†	a, b > c
RCFT delayed	13.49 ± 0.65	12.69 ± 1.25	5.66 ± 0.79	2.3E− 11^†	a, b > c
RCFT rec	18.92 ± 0.21	18.48 ± 0.40	17.19 ± 0.25	6.0E− 6^†	a, b > c
Executive function
Fluency A	13.35 ± 0.43	13.06 ± 0.82	11.70 ± 0.51	0.062	n.s
Fluency P	21.44 ± 0.85	22.68 ± 1.65	20.15 ± 1.06	0.402	n.s
Stroop	71.54 ± 2.27	63.13 ± 4.37	67.57 ± 2.79	0.201	n.s
TMT B	68.12 ± 5.16	89.58 ± 11.03	75.09 ± 7.11	0.196	n.s

Data are presented as means ± standard deviations. A and T classification system, for “A” (based on the value of CSF Aβ_1–42), and “T” (based on the value of CSF p-Tau₁₈₁). The following CSF thresholds were used: 385.822 pg/mL for Aβ_1–42, and 41.881 pg/mL for p-Tau₁₈₁
TMT trail making test, DSF digit span forward, DSB digit span backward, BNT Boston naming test (15 item), RCFT copy Rey complex figure test copy score, SVLT imm Seoul verbal learning test immediate recall score, SVLT delayed SVLT delayed recall score, SVLT rec SVLT recognition score, LM I Logical Memory immediate recall score, LM II Logical Memory, delayed recall score, LM rec Logical Memory recognition score, RCFT imm RCFT immediate recall score, RCFT delayed RCFT delayed recall score, RCFT rec RCFT, recognition score, Fluency A fluency score for animal, Fluency P fluency score for 3 Korean letters, Stroop Stroop score for color naming in color-word in incongruent condition
^aA-/T-
^bA+/T-
^cA+/T+
^†Significant group difference at the Bonferroni corrected level, p < 0.0028

ISSN: 1758-9193