From: BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
N | Cross-sectionala | Longitudinalb | |||||
---|---|---|---|---|---|---|---|
β | SE | p value | β | SE | p value | ||
ADNI dataset | |||||||
CSF Aβ42 | |||||||
All subjects | 1157 | 0.116 | 0.035 | 0.001 | |||
Male | 509 | 0.151 | 0.047 | 0.001 | |||
Female | 648 | 0.075 | 0.052 | 0.152 | |||
ε4 non-carrier | 613 | 0.109 | 0.049 | 0.028 | |||
ε4 carrier | 544 | 0.120 | 0.049 | 0.014 | |||
Amyloid (−) | 314 | 0.052 | 0.035 | 0.131 | |||
Amyloid (+) | 843 | 0.099 | 0.034 | 0.004 | |||
ADAS-cog 13 | |||||||
All subjects | 1495 | − 0.194 | 0.070 | 0.006 | − 0.035 | 0.016 | 0.024 |
Male | 850 | − 0.210 | 0.086 | 0.014 | − 0.021 | 0.019 | 0.277 |
Female | 645 | − 0.166 | 0.117 | 0.158 | − 0.051 | 0.025 | 0.044 |
ε4 non-carrier | 786 | − 0.147 | 0.089 | 0.097 | − 0.027 | 0.016 | 0.091 |
ε4 carrier | 709 | − 0.185 | 0.104 | 0.076 | − 0.029 | 0.027 | 0.286 |
Amyloid (−) | 359 | − 0.081 | 0.099 | 0.413 | − 0.020 | 0.016 | 0.219 |
Amyloid (+) | 882 | − 0.255 | 0.095 | 0.008 | − 0.041 | 0.021 | 0.049 |
ROS/MAP dataset | |||||||
Global cognition score | |||||||
All subjects | 1084 | 0.065 | 0.041 | 0.116 | 0.024 | 0.010 | 0.020 |
Male | 361 | 0.029 | 0.075 | 0.696 | 0.007 | 0.017 | 0.670 |
Female | 723 | 0.089 | 0.048 | 0.067 | 0.032 | 0.013 | 0.012 |
ε4 non-carrier | 800 | 0.071 | 0.044 | 0.107 | 0.021 | 0.010 | 0.042 |
ε4 carrier | 284 | − 0.016 | 0.095 | 0.865 | 0.023 | 0.026 | 0.383 |