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Table 2 Association of BMI1 rs17415557 with CSF Aβ42 and cognitive function

From: BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease

 

N

Cross-sectionala

Longitudinalb

β

SE

p value

β

SE

p value

ADNI dataset

 CSF Aβ42

  All subjects

1157

0.116

0.035

0.001

   

  Male

509

0.151

0.047

0.001

   

  Female

648

0.075

0.052

0.152

   

  ε4 non-carrier

613

0.109

0.049

0.028

   

  ε4 carrier

544

0.120

0.049

0.014

   

  Amyloid (−)

314

0.052

0.035

0.131

   

  Amyloid (+)

843

0.099

0.034

0.004

   

 ADAS-cog 13

  All subjects

1495

− 0.194

0.070

0.006

− 0.035

0.016

0.024

  Male

850

− 0.210

0.086

0.014

− 0.021

0.019

0.277

  Female

645

− 0.166

0.117

0.158

− 0.051

0.025

0.044

  ε4 non-carrier

786

− 0.147

0.089

0.097

− 0.027

0.016

0.091

  ε4 carrier

709

− 0.185

0.104

0.076

− 0.029

0.027

0.286

  Amyloid (−)

359

− 0.081

0.099

0.413

− 0.020

0.016

0.219

  Amyloid (+)

882

− 0.255

0.095

0.008

− 0.041

0.021

0.049

ROS/MAP dataset

 Global cognition score

  All subjects

1084

0.065

0.041

0.116

0.024

0.010

0.020

  Male

361

0.029

0.075

0.696

0.007

0.017

0.670

  Female

723

0.089

0.048

0.067

0.032

0.013

0.012

  ε4 non-carrier

800

0.071

0.044

0.107

0.021

0.010

0.042

  ε4 carrier

284

− 0.016

0.095

0.865

0.023

0.026

0.383

  1. ADNI Alzheimer’s Disease Neuroimaging Initiatives, CSF cerebrospinal fluid, ADAS Alzheimer’s disease assessment scale, ROS Religious Orders Study, MAP Memory and Aging Project, amyloid beta
  2. aMultiple linear models accounting for age, sex, APOE genotype, and educational attainment were tested. Regression statistics of the main effect “rs17415557” in each model are shown
  3. bLinear mixed-effects models accounting for age, sex, APOE genotype, and educational attainment were tested. Regression statistics of the interaction term “rs17415557 * time” in each model are shown