From: Herpesvirus infections and Alzheimer’s disease: a Mendelian randomization study
Variable/phenotype | Sample size (cases/controls) | Case mean/median AAOa | Control mean/median AAEa | % female, cases/controls | Phenotype ascertainment |
---|---|---|---|---|---|
AD GWAS (secondary analysis) | 21,982/41944 | ||||
ADGC | 14,428/14562 | 71.1 | 76.2 | 59.3/59.3 | Autopsy or clinically confirmed from health care records |
CHARGE | 2137/13474 | 82.6 | 76.7 | 67.3/55.8 | |
EADI | 2240/6631 | 75.4 | 78.9 | 65/60.6 | |
GERAD | 3177/7277 | 73.0 | 51.0 | 64/51.8 | |
Herpesvirus infection GWAS | |||||
Chicken pox | 107,769/15982 | 45–60 | 45–60 | 51.9/37.0 | Self-report questionnaires; vaccinated individuals were excluded from the controls in the chickenpox study |
Shingles | 16,711/118152 | > 60 | 45–60 | 55.4/48.4 | |
Cold sores | 25,108/63332 | 45–60 | 45–60 | 52.0/45.2 | |
Mononucleosis | 17,457/68446 | 45–60 | 45–60 | 60.5/50.3 |